Vaccination against Helicobacter pylori--an old companion of man

Details

Serval ID
serval:BIB_D560A1092416
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Vaccination against Helicobacter pylori--an old companion of man
Journal
Expert Opinion on Biological Therapy
Author(s)
Keller  W. C., Michetti  P.
ISSN
1471-2598 (Print)
Publication state
Published
Issued date
09/2001
Volume
1
Number
5
Pages
795-802
Notes
Journal Article
Review --- Old month value: Sep
Abstract
Helicobacter pylori infection induces an important systemic and mucosal antibody response and a predominant Th1 cellular response. These immune responses, although powerful, fail to eliminate the infection. Studies in animals have shown that prophylactic and therapeutic immunisations are efficacious, although complete protective immunity has usually not been achieved. Initial human trials with recombinant urease showed that a mucosal immune response can be obtained following immunisations, with a decrease in bacterial density, but successful immunisation is still awaited. Progress is being made in several areas of vaccine design. A human vaccine against H. pylori would be favourable in terms of health benefits and costs in developed and developing countries.
Keywords
Animals Bacterial Vaccines/*therapeutic use Helicobacter Infections/immunology/*prevention & control Helicobacter pylori/drug effects/*immunology Humans Vaccination/*methods
Pubmed
Web of science
Create date
25/01/2008 16:02
Last modification date
20/08/2019 15:55
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