ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients.

Details

Serval ID
serval:BIB_D538B3877898
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients.
Journal
Journal of Antimicrobial Chemotherapy
Author(s)
Alanio A., Hauser P.M., Lagrou K., Melchers W.J., Helweg-Larsen J., Matos O., Cesaro S., Maschmeyer G., Einsele H., Donnelly J.P., Cordonnier C., Maertens J., Bretagne S., 5th European Conference on Infections in Leukemia (ECIL-5)  a joint venture of The European Group for Blood, Marrow Transplantation (EBMT)  The European Organization for Research, Treatment of Cancer (EORTC)  the Immunocompromised Host Society (ICHS)
Working group(s)
The European LeukemiaNet (ELN)
Contributor(s)
Agrawal S., Akova M., Alanio A., Aljurf M., Averbuch D., Berg T., Blennow O., Bretagne S., Brüggemann R., Calandra T., Castagnola E., Cesaro S., Cordonnier C., Cornely O., De La Camara R., Donnelly P., Drgona L., Duarte R., Einsele H., Engelhard D., Girmenia C., Hargreaves R., Hauser P., Helweg-Larsen J., Herbrecht R., Hirsch H., Hubacek P., Kibbler C., Klyasova G., Kouba M., Kullberg BJ., Lagrou K., Ljungman P., Maertens J., Mallet V., Marchetti O., Maschmeyer G., Matos O., Melchers W., Mikulska M., Munoz P., Orasch C., Pagano L., Pagliuca A., Penack O., Pettrikos G., Racil Z., Ribaud P., Rizzi-Puechal V., Roilides E., Sinko J., Skiada A., Slavin M., Styczynski J., Tissot F., Tweddle L., van Boemmel F., von Lilienfeld-Toal M., Viscoli C., Ward K., Wood C.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
71
Number
9
Pages
2386-2396
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The Fifth European Conference on Infections in Leukaemia (ECIL-5) convened a meeting to establish evidence-based recommendations for using tests to diagnose Pneumocystis jirovecii pneumonia (PCP) in adult patients with haematological malignancies. Immunofluorescence assays are recommended as the most sensitive microscopic method (recommendation A-II: ). Real-time PCR is recommended for the routine diagnosis of PCP ( A-II: ). Bronchoalveolar lavage (BAL) fluid is recommended as the best specimen as it yields good negative predictive value ( A-II: ). Non-invasive specimens can be suitable alternatives ( B-II: ), acknowledging that PCP cannot be ruled out in case of a negative PCR result ( A-II: ). Detecting β-d-glucan in serum can contribute to the diagnosis but not the follow-up of PCP ( A-II: ). A negative serum β-d-glucan result can exclude PCP in a patient at risk ( A-II: ), whereas a positive test result may indicate other fungal infections. Genotyping using multilocus sequence markers can be used to investigate suspected outbreaks ( A-II: ). The routine detection of dihydropteroate synthase mutations in cases of treatment failure is not recommended ( B-II: ) since these mutations do not affect response to high-dose co-trimoxazole. The clinical utility of these diagnostic tests for the early management of PCP should be further assessed in prospective, randomized interventional studies.
Pubmed
Web of science
Open Access
Yes
Create date
16/09/2016 16:01
Last modification date
20/08/2019 16:55
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