CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.

Details

Serval ID
serval:BIB_D53515764F1B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
Journal
European journal of immunology
Author(s)
Speiser D.E., Valmori D., Rimoldi D., Pittet M.J., Liénard D., Cerundolo V., MacDonald H.R., Cerottini J.C., Romero P.
ISSN
0014-2980
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
29
Number
6
Pages
1990-1999
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
In humans, NK receptors are expressed by natural killer cells and some T cells, the latter of which are preferentially alphabetaTCR+ CD8+ cytolytic T lymphocytes (CTL). In this study we analyzed the expression of nine NK receptors (p58.1, p58.2, p70, p140, ILT2, NKRP1A, ZIN176, CD94 and CD94/NKG2A) in PBL from both healthy donors and melanoma patients. The percentages of NK receptor-positive T cells (NKT cells) varied strongly, and this variation was more important between individual patients than between individual healthy donors. In all the individuals, the NKT cells were preferentially CD28-, and a significant correlation was found between the percentage of CD28- T cells and the percentage of NK receptor+ T cells. Based on these data and the known activated phenotype of CD28- T cells, we propose that the CD28- CD8+ T cell pool represents or contains the currently active CTL population, and that the frequent expression of NK receptors reflects regulatory mechanisms modulating the extent of CTL effector function. Preliminary results indicate that some tumor antigen-specific T cells may indeed be CD28- and express NK receptors in vivo.
Keywords
Adult, Aged, Amino Acid Sequence, Antigens, CD, Antigens, CD28/metabolism, Antigens, Neoplasm/genetics, CD8-Positive T-Lymphocytes/immunology, Case-Control Studies, Female, Fetal Blood/cytology, Fetal Blood/immunology, Humans, Infant, Newborn, Killer Cells, Natural/immunology, Lymphocyte Count, Male, Melanoma/immunology, Middle Aged, Receptors, Antigen, T-Cell, alpha-beta/metabolism, Receptors, Immunologic/blood, Receptors, Immunologic/metabolism, T-Lymphocytes, Cytotoxic/immunology
Pubmed
Web of science
Create date
28/01/2008 11:13
Last modification date
20/08/2019 15:55
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