Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteers.
Details
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State: Public
Version: Final published version
State: Public
Version: Final published version
Serval ID
serval:BIB_D520380EB7FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteers.
Journal
Basic and Clinical Pharmacology and Toxicology
ISSN
1742-7843 (Electronic)
ISSN-L
1742-7835
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
112
Number
2
Pages
132-137
Language
english
Notes
Publication types: Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The new anti-aggregating agent prasugrel is bioactivated by cytochromes P450 (CYP) 3A and 2B6. Ritonavir is a potent CYP3A inhibitor and was shown in vitro as a CYP2B6 inhibitor. The aim of this open-label cross-over study was to assess the effect of ritonavir on prasugrel active metabolite (prasugrel AM) pharmacokinetics in healthy volunteers. Ten healthy male volunteers received 10 mg prasugrel. After at least a week washout, they received 100 mg ritonavir, followed by 10 mg prasugrel 2 hr later. We used dried blood spot sampling method to monitor prasugrel AM pharmacokinetics (C(max) , t(1/2) , t(max) , AUC(0-6 hr) ) at 0, 0.25, 0.5, 1, 1.5, 2, 4 and 6 hr after prasugrel administration. A 'cocktail' approach was used to measure CYP2B6, 2C9, 2C19 and 3A activities. In the presence of ritonavir, prasugrel AM C(max) and AUC were decreased by 45% (mean ratio: 0.55, CI 90%: 0.40-0.7, p = 0.007) and 38% (mean ratio: 0.62, CI 90%: 0.54-0.7, p = 0.005), respectively, while t(1/2) and t(max) were not affected. Midazolam metabolic ratio (MR) dramatically decreased in presence of ritonavir (6.7 ± 2.6 versus 0.13 ± 0.07) reflecting an almost complete inhibition of CYP3A4, whereas omeprazole, flurbiprofen and bupropion MR were not affected. These data demonstrate that ritonavir is able to block prasugrel CYP3A4 bioactivation. This CYP-mediated drug-drug interaction might lead to a significant reduction of prasugrel efficacy in HIV-infected patients with acute coronary syndrome.
Keywords
Adult, Area Under Curve, Cross-Over Studies, Cytochrome P-450 CYP3A/metabolism, Cytochrome P-450 CYP3A Inhibitors, Drug Interactions, HIV Protease Inhibitors/pharmacokinetics, HIV Protease Inhibitors/pharmacology, Half-Life, Humans, Male, Midazolam/metabolism, Piperazines/pharmacokinetics, Prasugrel Hydrochloride, Ritonavir/pharmacology, Thiophenes/pharmacokinetics, Time Factors, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
10/08/2016 11:22
Last modification date
20/08/2019 16:54