Developing psychosis and its risk States through the lens of schizotypy.

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State: Public
Version: author
Serval ID
serval:BIB_D4FC3C25410B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Developing psychosis and its risk States through the lens of schizotypy.
Journal
Schizophrenia Bulletin
Author(s)
Debbané M., Eliez S., Badoud D., Conus P., Flückiger R., Schultze-Lutter F.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
41 Suppl 2
Pages
S396-S407
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Starting from the early descriptions of Kraepelin and Bleuler, the construct of schizotypy was developed from observations of aberrations in nonpsychotic family members of schizophrenia patients. In contemporary diagnostic manuals, the positive symptoms of schizotypal personality disorder were included in the ultra high-risk (UHR) criteria 20 years ago, and nowadays are broadly employed in clinical early detection of psychosis. The schizotypy construct, now dissociated from strict familial risk, also informed research on the liability to develop any psychotic disorder, and in particular schizophrenia-spectrum disorders, even outside clinical settings. Against the historical background of schizotypy it is surprising that evidence from longitudinal studies linking schizotypy, UHR, and conversion to psychosis has only recently emerged; and it still remains unclear how schizotypy may be positioned in high-risk research. Following a comprehensive literature search, we review 18 prospective studies on 15 samples examining the evidence for a link between trait schizotypy and conversion to psychosis in 4 different types of samples: general population, clinical risk samples according to UHR and/or basic symptom criteria, genetic (familial) risk, and clinical samples at-risk for a nonpsychotic schizophrenia-spectrum diagnosis. These prospective studies underline the value of schizotypy in high-risk research, but also point to the lack of evidence needed to better define the position of the construct of schizotypy within a developmental psychopathology perspective of emerging psychosis and schizophrenia-spectrum disorders.
Pubmed
Web of science
Open Access
Yes
Create date
23/01/2015 14:46
Last modification date
20/08/2019 15:54
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