Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA
Details
Serval ID
serval:BIB_D4C4AC55EE07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA
Journal
Journal of Clinical Investigation
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
03/2000
Volume
105
Number
6
Pages
777-82
Notes
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't --- Old month value: Mar
Multicenter Study
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
Effective therapeutic interventions and clinical care of adults infected with HIV-1 require an understanding of factors that influence time of response to antiretroviral therapy. We have studied a cohort of 118 HIV-1-infected subjects naive to antiretroviral therapy and have correlated the time of response to treatment with a series of virological and immunological measures, including levels of viral load in blood and lymph node, percent of CD4 T cells in lymph nodes, and CD4 T-cell count in blood at study entry. Suppression of viremia below the limit of detection, 50 HIV-1 RNA copies/mL of plasma, served as a benchmark for a successful virological response. We employed these correlations to predict the length of treatment required to attain a virological response in each patient. Baseline plasma viremia emerged as the factor most tightly correlated with the duration of treatment required, allowing us to estimate the required time as a function of this one measure.
Keywords
Adult
Anti-HIV Agents/*administration & dosage/pharmacology/therapeutic use
CD4 Lymphocyte Count/drug effects
CD4-Positive T-Lymphocytes/pathology
Carbamates
Cohort Studies
Dideoxynucleosides/administration & dosage/pharmacology/therapeutic use
HIV Infections/*drug therapy/immunology/virology
HIV Protease Inhibitors/administration & dosage/pharmacology/therapeutic
use
HIV-1/*isolation & purification
HIV-1 Reverse Transcriptase/antagonists & inhibitors
Humans
Lamivudine/administration & dosage/pharmacology/therapeutic use
Lymph Nodes/virology
Nelfinavir/administration & dosage/pharmacology/therapeutic use
RNA, Viral/*blood
Reverse Transcriptase Inhibitors/administration &
dosage/pharmacology/therapeutic use
Saquinavir/administration & dosage/pharmacology/therapeutic use
Stavudine/administration & dosage/pharmacology/therapeutic use
Sulfonamides/administration & dosage/pharmacology/therapeutic use
Time Factors
*Viral Load
Viremia/*drug therapy
Zidovudine/administration & dosage/pharmacology/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:13
Last modification date
20/08/2019 15:54