Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland.

Details

Serval ID
serval:BIB_D49F490C8CD6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland.
Journal
Pediatric Infectious Disease Journal
Author(s)
Myers C., Posfay-Barbe K.M., Aebi C., Cheseaux J.J., Kind C., Rudin C., Nadal D., Siegrist C.A.
Working group(s)
Pediatric Infectious Disease Group of Switzerland (PIGS), Swiss Mother, Child HIV Cohort Study (MoCHIV)
Contributor(s)
Aebi C., Bär W., Berger Ch., Besson F., Bühlmann U., Cheseaux JJ., Desgrandchamps D., Diana A., Duppenthaler A., Gervaix A., Gnehm HP., Heininger U., Hunzikerr UA., Kahlert C., Kind C., Kuchler H., Loher A., Masserey-Spicher V., Myers C., Nadal D., Posfay-Barbe K., Rudin C., Schaad UB., Siegrist CA., Stähelin J., Vaudaux B., Wyler-Lazarevic CA., Zingg W., Battegay M., Bernasconi E., Böni J., Brazzola P., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Drack G., Dubs R., Egger M., Elzi L., Fischer M., Flepp M., Fontana A., Francioli P., Furrer HJ., Fux C., Gayet-Ageron A., Gerber S., Gorgievski M., Gunthard H., Gyr T., Hirsch H., Hirschel B., Hösli I., Hüsler M., Kaiser L., Kahlert Ch., Karrer U., Klimkait T., Ledergerber B., Martinetti G., Martinez B., Müller N., Nadal D., Paccaud F., Pantaleo G., Raio L., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., Weber R., Wyler CA., Yerly S.
ISSN
1532-0987 (Electronic)
ISSN-L
0891-3668
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
28
Number
11
Pages
996-1001
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued.
METHODS: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity.
RESULTS: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center.
CONCLUSIONS: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.
Keywords
Adolescent, Antibodies, Viral/blood, CD4 Lymphocyte Count, Child, Child, Preschool, Cohort Studies, Female, Guideline Adherence/statistics & numerical data, HIV Infections/immunology, Humans, Male, Prospective Studies, Switzerland, Vaccination/utilization, Vaccines/immunology, Viral Load, Young Adult
Pubmed
Web of science
Create date
19/11/2009 16:38
Last modification date
20/08/2019 15:54
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