Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Gulia-Nuss, M.; Nuss, A.B.; Meyer, J.M.; Sonenshine, D.E.; Roe, R.M.; Waterhouse, R.M.; Sattelle, D.B.; de la Fuente, J.; Ribeiro, J.M.; Megy, K.; Thimmapuram, J.; Miller, J.R.; Walenz, B.P.; Koren, S.; Hostetler, J.B.; Thiagarajan, M.; Joardar, V.S.; Hannick, L.I.; Bidwell, S.; Hammond, M.P.; Young, S.; Zeng, Q.; Abrudan, J.L.; Almeida, F.C.; Ayllón, N.; Bhide, K.; Bissinger, B.W.; Bonzon-Kulichenko, E.; Buckingham, S.D.; Caffrey, D.R.; Caimano, M.J.; Croset, V.; Driscoll, T.; Gilbert, D.; Gillespie, J.J.; Giraldo-Calderón, G.I.; Grabowski, J.M.; Jiang, D.; Khalil, S.M.; Kim, D.; Kocan, K.M.; Koči, J.; Kuhn, R.J.; Kurtti, T.J.; Lees, K.; Lang, E.G.; Kennedy, R.C.; Kwon, H.; Perera, R.; Qi, Y.; Radolf, J.D.; Sakamoto, J.M.; Sánchez-Gracia, A.; Severo, M.S.; Silverman, N.; Šimo, L.; Tojo, M.; Tornador, C.; Van Zee, J.P.; Vázquez, J.; Vieira, F.G.; Villar, M.; Wespiser, A.R.; Yang, Y.; Zhu, J.; Arensburger, P.; Pietrantonio, P.V.; Barker, S.C.; Shao, R.; Zdobnov, E.M.; Hauser, F.; Grimmelikhuijzen, C.J.; Park, Y.; Rozas, J.; Benton, R.; Pedra, J.H.; Nelson, D.R.; Unger, M.F.; Tubio, J.M.; Tu, Z.; Robertson, H.M.; Shumway, M.; Sutton, G.; Wortman, J.R.; Lawson, D.; Wikel, S.K.; Nene, V.M.; Fraser, C.M.; Collins, F.H.; Birren, B.; Nelson, K.E.; Caler, E.; Hill, C.A.

doi:10.1038/ncomms10507

Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Details

Download: ncomms10507.pdf (3261.76 [Ko])
State: Public
Version: Final published version
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Serval ID

serval:BIB_D4988D4D9151

Type

Article: article from journal or magazin.

Publication sub-type

Minutes: analyse of a published work.

Collection

Publications

Institution

UNIL/CHUV

Title

Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Journal

Nature Communications

Author(s)

Gulia-Nuss M., Nuss A.B., Meyer J.M., Sonenshine D.E., Roe R.M., Waterhouse R.M., Sattelle D.B., de la Fuente J., Ribeiro J.M., Megy K., Thimmapuram J., Miller J.R., Walenz B.P., Koren S., Hostetler J.B., Thiagarajan M., Joardar V.S., Hannick L.I., Bidwell S., Hammond M.P., Young S., Zeng Q., Abrudan J.L., Almeida F.C., Ayllón N., Bhide K., Bissinger B.W., Bonzon-Kulichenko E., Buckingham S.D., Caffrey D.R., Caimano M.J., Croset V., Driscoll T., Gilbert D., Gillespie J.J., Giraldo-Calderón G.I., Grabowski J.M., Jiang D., Khalil S.M., Kim D., Kocan K.M., Koči J., Kuhn R.J., Kurtti T.J., Lees K., Lang E.G., Kennedy R.C., Kwon H., Perera R., Qi Y., Radolf J.D., Sakamoto J.M., Sánchez-Gracia A., Severo M.S., Silverman N., Šimo L., Tojo M., Tornador C., Van Zee J.P., Vázquez J., Vieira F.G., Villar M., Wespiser A.R., Yang Y., Zhu J., Arensburger P., Pietrantonio P.V., Barker S.C., Shao R., Zdobnov E.M., Hauser F., Grimmelikhuijzen C.J., Park Y., Rozas J., Benton R., Pedra J.H., Nelson D.R., Unger M.F., Tubio J.M., Tu Z., Robertson H.M., Shumway M., Sutton G., Wortman J.R., Lawson D., Wikel S.K., Nene V.M., Fraser C.M., Collins F.H., Birren B., Nelson K.E., Caler E., Hill C.A.

ISSN

2041-1723 (Electronic)

ISSN-L

2041-1723

Publication state

Published

Issued date

2016

Peer-reviewed

Oui

Volume

Number

10507

Pages

10507

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: epublish

Abstract

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.

Keywords

Anaplasma phagocytophilum, Animals, Arachnid Vectors/genetics, Gene Expression Profiling, Genome/genetics, Genomics, Ixodes/genetics, Ligand-Gated Ion Channels/genetics, Lyme Disease/transmission, Oocytes, Xenopus laevis

URN

urn:nbn:ch:serval-BIB_D4988D4D91517

OAI-PMH

oai:serval.unil.ch:BIB_D4988D4D9151

DOI

10.1038/ncomms10507

Pubmed

26856261

Web of science

000371012500004

Open Access

Yes