Genomic insights into the Ixodes scapularis tick vector of Lyme disease.

Details

Ressource 1Download: ncomms10507.pdf (3261.76 [Ko])
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_D4988D4D9151
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Institution
Title
Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Journal
Nature Communications
Author(s)
Gulia-Nuss M., Nuss A.B., Meyer J.M., Sonenshine D.E., Roe R.M., Waterhouse R.M., Sattelle D.B., de la Fuente J., Ribeiro J.M., Megy K., Thimmapuram J., Miller J.R., Walenz B.P., Koren S., Hostetler J.B., Thiagarajan M., Joardar V.S., Hannick L.I., Bidwell S., Hammond M.P., Young S., Zeng Q., Abrudan J.L., Almeida F.C., Ayllón N., Bhide K., Bissinger B.W., Bonzon-Kulichenko E., Buckingham S.D., Caffrey D.R., Caimano M.J., Croset V., Driscoll T., Gilbert D., Gillespie J.J., Giraldo-Calderón G.I., Grabowski J.M., Jiang D., Khalil S.M., Kim D., Kocan K.M., Koči J., Kuhn R.J., Kurtti T.J., Lees K., Lang E.G., Kennedy R.C., Kwon H., Perera R., Qi Y., Radolf J.D., Sakamoto J.M., Sánchez-Gracia A., Severo M.S., Silverman N., Šimo L., Tojo M., Tornador C., Van Zee J.P., Vázquez J., Vieira F.G., Villar M., Wespiser A.R., Yang Y., Zhu J., Arensburger P., Pietrantonio P.V., Barker S.C., Shao R., Zdobnov E.M., Hauser F., Grimmelikhuijzen C.J., Park Y., Rozas J., Benton R., Pedra J.H., Nelson D.R., Unger M.F., Tubio J.M., Tu Z., Robertson H.M., Shumway M., Sutton G., Wortman J.R., Lawson D., Wikel S.K., Nene V.M., Fraser C.M., Collins F.H., Birren B., Nelson K.E., Caler E., Hill C.A.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
7
Number
10507
Pages
10507
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: epublish
Abstract
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Keywords
Anaplasma phagocytophilum, Animals, Arachnid Vectors/genetics, Gene Expression Profiling, Genome/genetics, Genomics, Ixodes/genetics, Ligand-Gated Ion Channels/genetics, Lyme Disease/transmission, Oocytes, Xenopus laevis
Pubmed
Web of science
Open Access
Yes
Create date
13/12/2015 9:09
Last modification date
04/01/2020 7:17
Usage data