The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.

Details

Serval ID
serval:BIB_D47EB451137F
Type
Article: article from journal or magazin.
Collection
Publications
Title
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.
Journal
Blood
Author(s)
de Leval L., Rickman D.S., Thielen C., Reynies A., Huang Y.L., Delsol G., Lamant L., Leroy K., Brière J., Molina T., Berger F., Gisselbrecht C., Xerri L., Gaulard P.
ISSN
0006-4971[print], 0006-4971[linking]
Publication state
Published
Issued date
2007
Volume
109
Number
11
Pages
4952-4963
Language
english
Abstract
The molecular alterations underlying the pathogenesis of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unspecified (PTCL-u) are largely unknown. In order to characterize the ontogeny and molecular differences between both entities, a series of AITLs (n = 18) and PTCLs-u (n = 16) was analyzed using gene expression profiling. Unsupervised clustering correlated with the pathological classification and with CD30 expression in PTCL-u. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell- and follicular dendritic cell-related genes, chemokines, and genes related to extracellular matrix and vascular biology), and overexpression of several genes characteristic of normal follicular helper T (T(FH)) cells (CXCL13, BCL6, PDCD1, CD40L, NFATC1). By gene set enrichment analysis, the AITL molecular signature was significantly enriched in published T(FH)-specific genes. The enrichment was higher for sorted AITL cells than for tissue samples. Overexpression of several T(FH) genes was validated by immunohistochemistry in AITLs. A few cases with molecular T(FH)-like features were identified among CD30(-) PTCLs-u. Our findings strongly support that T(FH) cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30(-) PTCLs-u may derive from or be related to AITL.
Keywords
Adult, Aged, Aged, 80 and over, Antigens, CD27/biosynthesis, Antigens, CD30/biosynthesis, Cluster Analysis, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Lymphoma, T-Cell, Peripheral/immunology, Lymphoma, T-Cell, Peripheral/metabolism, Male, Middle Aged, Models, Genetic
Pubmed
Create date
27/10/2010 8:56
Last modification date
20/08/2019 15:54
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