Mediastinal and hilar lymphadenopathy due to Pneumocystis carinii infection in AIDS patients: CT features.

Details

Serval ID
serval:BIB_D45BE4401E33
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mediastinal and hilar lymphadenopathy due to Pneumocystis carinii infection in AIDS patients: CT features.
Journal
Journal of Computer Assisted Tomography
Author(s)
Mayor B., Schnyder P., Giron J., Landry M., Duvoisin B., Fournier D.
ISSN
0363-8715
Publication state
Published
Issued date
06/1994
Peer-reviewed
Oui
Volume
18
Number
3
Pages
408-411
Language
english
Abstract
OBJECTIVE: Extrapulmonary involvement by Pneumocystis carinii (PC) in acquired immunodeficiency syndrome (AIDS) patients is uncommon. Our purpose is to describe three AIDS patients with low cluster differentiation cell (CD4) counts, who were receiving aerosol pentamidine prophylaxis, and who had large noncalcified hilar and mediastinal lymphadenopathy. MATERIALS AND METHODS: Chest radiography, CT, and clinical and laboratory records of three AIDS patients who had radiographic evidence of mediastinal and hilar lymphadenopathy were retrospectively reviewed. RESULTS: Symptoms were quite similar in all patients: weight loss, fever, cough, and mild dyspnea. Mediastinal and hilar widening was noticed on chest radiography. Contrast-enhanced chest CT revealed multiple noncalcified lymphadenopathy with supracarinal predominance in all cases. Mediastinoscopy with mediastinal and hilar lymph nodes sampling was performed in all patients. Histologic examination of the biopsy specimens demonstrated a necrotic foamy tissue without any calcification, and silver stain coloration showed abundant PC organisms in each case. CONCLUSION: In AIDS patients, PC infection should be considered as a possible cause of noncalcified hilar and mediastinal lymphadenopathy along with such possibilities as atypical infections and neoplasms, especially in severely immunocompromised hosts (low CD4) with aerosol pentamidine prophylaxis.
Keywords
AIDS-Related Opportunistic Infections/pathology, AIDS-Related Opportunistic Infections/radiography, Adult, Female, Humans, Lymph Nodes/pathology, Lymphatic Diseases/pathology, Lymphatic Diseases/radiography, Male, Mediastinal Diseases/radiography, Pneumocystis Infections/complications, Pneumocystis Infections/pathology, Radiography, Thoracic, Retrospective Studies, Tomography, X-Ray Computed
Pubmed
Web of science
Create date
11/04/2008 11:40
Last modification date
20/08/2019 15:54
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