Latest Insights on the Relationship Between Symptoms and Biologic Findings in Adults with Eosinophilic Esophagitis.
Details
Serval ID
serval:BIB_D459A0BD5F3B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Latest Insights on the Relationship Between Symptoms and Biologic Findings in Adults with Eosinophilic Esophagitis.
Journal
Gastrointestinal endoscopy clinics of North America
ISSN
1558-1950 (Electronic)
ISSN-L
1052-5157
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
28
Number
1
Pages
35-45
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Patients with eosinophilic esophagitis (EoE) present with symptoms accompanied by behavioral adaptions to living with this condition. These include swallowing- and nonswallowing-associated pain in adulthood. In children, EoE symptoms vary with age and include vomiting, abdominal pain, and dysphagia. Studies using validated patient-reported outcome measures have demonstrated that symptoms in EoE are associated with severe biologic alterations and that patients on the low biologic severity spectrum have few symptoms. This nonlinear nature of the relationship between symptoms and biologic findings has important implications for among other things the length of diagnostic delay, selection of patients for clinical trials, trial duration, and long-term management of EoE patients.
Keywords
Clinical Trials as Topic, Deglutition Disorders/etiology, Delayed Diagnosis, Eosinophilic Esophagitis/complications, Eosinophilic Esophagitis/diagnosis, Eosinophilic Esophagitis/drug therapy, Eosinophilic Esophagitis/pathology, Humans, Pain/etiology, Patient Reported Outcome Measures, Patient Selection, Severity of Illness Index, Symptom Assessment/methods, Eosinophilic esophagitis, Patient-reported outcomes, Quality of life, Regulatory authorities, Symptoms
Pubmed
Create date
22/11/2017 8:52
Last modification date
20/08/2019 15:54