Association of statins with inflammatory cytokines: a population-based Colaus study.

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State: Public
Version: author
Serval ID
serval:BIB_D4370ECBB447
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of statins with inflammatory cytokines: a population-based Colaus study.
Journal
Atherosclerosis
Author(s)
Lyngdoh T., Vollenweider P., Waeber G., Marques-Vidal P.
ISSN
1879-1484 (Electronic)
ISSN-L
0021-9150
Publication state
Published
Issued date
11/2011
Peer-reviewed
Oui
Volume
219
Number
1
Pages
253-258
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
A pleiotropic effect of statins has been reported in numerous studies. However, the association between statin use and inflammatory cytokines is controversial. We examined the associations between statin use and C-reactive protein (CRP), tumour necrosis factor α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in a healthy Caucasian population.
Cross-sectional study of 6184 participants aged 35-75 years from Lausanne, Switzerland. Cytokines were assessed by multiplexed particle-based flow cytometric assay. Self-reported history of medication was collected for statins and other medication. 99 participants without cytokine data were excluded.
Among the 6085 participants, 2289 (37.6%), 451 (7.4%) and 43 (0.7%) had IL-1β, IL-6 and TNF-α levels below detection limits, respectively. On multivariate analysis adjusting for age, gender, smoking status, body mass index, hypertension, diabetes, baseline cardiovascular disease, total cholesterol, anti-inflammatory use, other cytokine modifying drugs and other drugs, participants on statins had significantly lower CRP levels (adjusted mean±standard error: 1.22±1.05 vs. 1.38±1.04 mg/L for use and non-use, respectively, p<0.01 on log-transformed data). Conversely, no association was found between statin use and IL-1β (p=0.91), IL-6 (p=0.25) or TNF-α (p=0.28) levels. On multivariate analysis, individuals in the statin group (β coefficient=-0.12; 95% CI=-0.21, -0.03) had lower levels of CRP as compared to those in the reference group (i.e. those not using statin). However, no significant associations were observed between IL-1β, IL-6 and TNF-α and statins.
Individuals on statins have lower CRP levels; conversely, no effect was found for IL-1β, IL-6 and TNF-α levels.

Keywords
Adult, Aged, C-Reactive Protein/metabolism, Cardiovascular Diseases/drug therapy, Cohort Studies, Cross-Sectional Studies, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Inflammation/drug therapy, Interleukin-1beta/metabolism, Interleukin-6/metabolism, Male, Middle Aged, Switzerland, Tumor Necrosis Factor-alpha/metabolism
Pubmed
Web of science
Create date
23/08/2011 13:45
Last modification date
20/08/2019 16:54
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