Aortic remodelling in Fabry disease

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Serval ID
serval:BIB_D432A86025C6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Aortic remodelling in Fabry disease
Journal
European Heart Journal
Author(s)
Barbey F., Qanadli S.D., Juli C., Brakch N., Palacek T., Rizzo E., Jeanrenaud X., Eckhardt B., Linhart A.
ISSN
1522-9645
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
31
Number
3
Pages
347-353
Language
english
Abstract
Aims To evaluate thoracic aortic dilation in patients with Fabry disease (FD). Methods and results A cohort of 106 patients with FD (52 males; 54 females) from three European centres were studied. The diameter of the thoracic aorta was assessed at three levels (sinus of Valsalva, ascending aorta, and descending aorta) using echocardiograms and cardiovascular magnetic resonance imaging. Aortic dilation at the sinus of Valsalva was found in 32.7% of males and 5.6% of females; aneurysms were present in 9.6% of males and 1.9% of females. No aortic dilation was observed in the descending aorta. There was no correlation between aortic diameter at the sinus of Valsalva and cardiovascular risk factors. Conclusion Fabry disease should be considered as a cardiovascular disease that affects the heart and arterial vasculature, including the thoracic aorta. Thus, patients with FD should be closely monitored for the presence, and possible progression and complications of aortic dilation. Clinical Trial Registration: Protocol 101/01. Ethics committee, Faculty of Medicine, Lausanne.
Pubmed
Web of science
Open Access
Yes
Create date
03/11/2009 17:55
Last modification date
25/09/2019 7:10
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