Tumor dormancy: EMT beyond invasion and metastasis.

Details

Ressource 1Download: 37776086.pdf (2099.07 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D431AF179704
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tumor dormancy: EMT beyond invasion and metastasis.
Journal
Genesis
Author(s)
Aouad P., Quinn H.M., Berger A., Brisken C.
ISSN
1526-968X (Electronic)
ISSN-L
1526-954X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from disseminated tumor cells (DTCs) that leave the primary tumor early on in tumor development, either as single cells or clusters, adapt to new environments, and reduce or shut down their proliferation entering a state of dormancy for prolonged periods of time. Dormancy has been difficult to track clinically and study experimentally. Recent advances in technology and disease modeling have provided new insights into the molecular mechanisms orchestrating dormancy and the switch to a proliferative state. A new role for epithelial-mesenchymal transition (EMT) in inducing plasticity and maintaining a dormant state in several cancer models has been revealed. In this review, we summarize the major findings linking EMT to dormancy control and highlight the importance of pre-clinical models and tumor/tissue context when designing studies. Understanding of the cellular and molecular mechanisms controlling dormant DTCs is pivotal in developing new therapeutic agents that prevent distant recurrence by maintaining a dormant state.
Keywords
cell cycle, disseminated tumor cells, dormancy, epithelial-mesenchymal plasticity, mesenchymal-epithelial transition
Pubmed
Web of science
Open Access
Yes
Create date
06/10/2023 15:30
Last modification date
03/02/2024 8:13
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