Safety and efficacy of chronic therapy with captopril in hypertensive patients: an update

Details

Serval ID
serval:BIB_D3F726B03C37
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Safety and efficacy of chronic therapy with captopril in hypertensive patients: an update
Journal
Journal of Clinical Pharmacology
Author(s)
Waeber B., Gavras I., Brunner  H. R., Gavras H.
ISSN
0091-2700
Publication state
Published
Issued date
1981
Peer-reviewed
Oui
Volume
21
Number
11-12 Pt 1
Pages
508-16
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Abstract
Captopril, an orally active angiotensin-converting enzyme inhibitor, has been administered to 81 patients with different types of clinical hypertension. Most of the patients had previously uncontrollable high blood pressure. In order to achieve a satisfactory blood pressure control during long-term captopril therapy, a concomitant decrease in total body sodium was required in more than half of the patients. During our first two years of clinical experience with this new antihypertensive agent, side effects developed in 46.9 per cent of the patients and necessitated the withdrawal of the drug in 23.4 per cent of all patients. Only a few side effects such as hypotensive or syncopal episodes and cold extremities appeared to be due to the chronic blockade of the renin-angiotensin system. The most frequent and the most serious adverse reactions such as skin rash, altered taste, pancytopenia, and pemphigus foliaceus seemed to be specifically drug related. The incidence of cutaneous and taste problems was markedly higher in patients with impaired renal function in whom retention of captopril has been previously demonstrated. This suggests that the occurrence of adverse reactions to captopril could be lowered in the future by using smaller daily doses and by titrating them according to the renal function.
Keywords
AdolescentAdultAgedBlood/drug effectsBlood Pressure/drug effectsCaptopril/*adverse effects/therapeutic useChildDrug EruptionsFemaleHumansHypertension/*drug therapyKidney/drug effectsMaleMiddle AgedPemphigus/chemically inducedPotassium/bloodProline/*analogs & derivativesProteinuria/chemically inducedTaste Disorders/chemically induced
Pubmed
Web of science
Create date
04/03/2009 15:04
Last modification date
20/08/2019 15:53
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