Transport systems and enzymes involved in the metamorphosis of tryptophan into serotonin

Details

Serval ID
serval:BIB_D3CF4617F349
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transport systems and enzymes involved in the metamorphosis of tryptophan into serotonin
Journal
Pharmacopsychiatry
Author(s)
Baumann Pierre
ISSN
0176-3679 (Print)
ISSN-L
0176-3679
Publication state
Published
Issued date
03/1985
Volume
18
Number
2
Pages
188-92
Language
english
Notes
Baumann, P
eng
Germany
Pharmacopsychiatry. 1985 Mar;18(2):188-92. doi: 10.1055/s-2007-1017362.
Abstract
Tryptophan (Trp), as the precursor of serotonin, has been introduced in the treatment of depression and isomnia, but its clinical effectiveness must be considered with caution. In this presentation, the different aspects concerning the transport of Trp from the intestine to the brain and its enzymatic conversion into serotonin are discussed. The study of recent literature shows that the discussion about the relative importance of free and total plasma Trp and of the competitive large neutral amino acids for the transport of Trp into the brain continues. On the other hand, mainly animal studies demonstrate numerous regulatory processes, the importance of which has been underestimated until today. These processes concern enzymes like indoleamine-2,3-dioxygenase, cleaving Trp, but also quinoid-dihydropteridine reductase, producing the tetrahydrobiopterin necessary for Trp hydroxylase. It is proposed that the different steps leading from Trp to functionally active 5-HT are considered in a more systemic approach, taking into account that 5-HT synthesis depends on factors like depolarization of the nerve cell, endproduct inhibition, etc. In man, further studies are needed concerning the fate of Trp and competing compounds in the blood, after long-term treatment with Trp. In order to influence enzymatic mechanisms, clinical trials with compounds like tetrahydrobiopterin, acting directly on the enzymatic conversion of Trp into 5-HT, could lend new impulses to research on precursor therapy.
Keywords
Animals, Biopterin/analogs & derivatives/metabolism, Biotransformation, Brain/*enzymology, Humans, Intestinal Absorption, Kinetics, Oxygenases/metabolism, Serotonin/*metabolism, Tryptamines/metabolism, Tryptophan/*metabolism, Tryptophan Hydroxylase/metabolism, Tryptophan Oxygenase
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Create date
11/01/2021 11:35
Last modification date
26/01/2021 6:26
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