Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Details

Serval ID
serval:BIB_D3C9ED3C3832
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
Journal
Nature Immunology
Author(s)
Paust Silke, Gill Harvinder S., Wang Bao-Zhong, Flynn Michael P., Moseman E. Ashley , Senman Balimkiz, Szczepanik Marian, Telenti Amalio, Askenase Philip W., Compans Richard W., von Andrian Ulrich H.
ISSN
1529-2916[electronic], 1529-2908[linking]
Publication state
Published
Issued date
2010
Volume
11
Number
12
Pages
1127-1135
Language
english
Abstract
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.
Keywords
Natural-Killer-Cells, Gamma Chain, T-Cells, Lymphoid Development, Influenza Infection, Adaptive Immunity, Dendritic Cells, HLA-B, Expression, Mice
Pubmed
Web of science
Create date
09/12/2010 9:32
Last modification date
20/08/2019 15:53
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