Age differences in renal response to atrial natriuretic peptide in rabbits

Details

Serval ID
serval:BIB_D3BD8BF25E1C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Age differences in renal response to atrial natriuretic peptide in rabbits
Journal
Life Sciences
Author(s)
Semmekrot  B. A., Wiesel  P. H., Monnens  L. A., Guignard  J. P.
ISSN
0024-3205 (Print)
Publication state
Published
Issued date
1990
Volume
46
Number
12
Pages
849-56
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
Plasma levels of atrial natriuretic peptide (ANP) and the effect of exogenous ANP on renal function have been studied in newborn and adult rabbits. In order to investigate an age difference in responsiveness to ANP, we studied the renal effects of alpha-human ANP (1-28) administered at the same dose per kg body weight in adult and neonatal rabbits. Plasma basal ANP levels were similar in 18 newborn (4- to 11-day-old) compared to 7 adult rabbits (150 +/- 16 and 151 +/- 28 pg/ml, resp.). Eleven newborn and 11 adult rabbits were anesthetized and mechanically ventilated. After a control period, each animal received an hANP loading dose (3 micrograms/kg i.v.), followed by an infusion of 0.3 micrograms/kg/min. Blood gases remained stable throughout the experiment in both groups. Mean blood pressure decreased in newborn (28.5 +/- 0.8 to 26.2 +/- 1.0 mmHg) and adult (92 +/- 3 to 84 +/- 3 mmHg) animals. Percent hANP-induced changes in renal functions in newborn and adult rabbits were, respectively: urine flow rate: -21 +/- 4% and +57 +/- 8%; urinary sodium excretion: +4 +/- 7% and +81 +/- 11%; glomerular filtration rate (GFR): -19 +/- 4% and -4 +/- 6%; renal blood flow (RBF): -22 +/- 4% and -11 +/- 5%. As expected, diuresis and natriuresis increased in adult rabbits. Failure of hANP to increase natriuresis and diuresis in newborn rabbits could be related to the marked decrease in GFR, receptor immaturity and/or interactions with other hormonal systems.
Keywords
Aging/*metabolism Animals Animals, Newborn Atrial Natriuretic Factor/blood/*pharmacology Blood Flow Velocity/drug effects Blood Pressure/drug effects Diuresis/drug effects Diuretics/*pharmacology Glomerular Filtration Rate/drug effects Kidney/drug effects/*metabolism Natriuresis/drug effects Peptide Fragments/*pharmacology Rabbits Renal Circulation/drug effects Sodium/urine Urination/drug effects
Pubmed
Web of science
Create date
25/01/2008 16:11
Last modification date
20/08/2019 15:53
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