Developmental regulation of carbonic anhydrase expression in mouse dorsal root ganglia.

Details

Serval ID
serval:BIB_D3B640075A1F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Developmental regulation of carbonic anhydrase expression in mouse dorsal root ganglia.
Journal
Brain research. Developmental brain research
Author(s)
Mayeux V., Tafti M., Baldy-Moulinier M., Valmier J.
ISSN
0165-3806
Publication state
Published
Issued date
02/1993
Peer-reviewed
Oui
Volume
71
Number
2
Pages
201-208
Language
english
Abstract
The development of proprioceptive neurons in mammalian dorsal root ganglia (DRG) remains poorly documented since few specific markers for these neurons are known. Recent studies suggest that carbonic anhydrase (CA) is a specific marker of this functionally defined neuronal population. The present study was designed to investigate the development of CA staining in sensory neurons. We investigated CA reactivity in mouse lumbar DRGs from embryonic day 13 (E13) to postnatal day 100 (P100) using a modified cytoenzymatic Hansson method. Neuronal CA reactivity was first detected during the perinatal stage (1-3% of DRG neurons) and increased progressively from P0 to P60 when it reached a plateau (about 30-33% of DRG neurons). Statistical morphometric analysis was used to define whether CA staining identifies the same population(s) during development. The results demonstrated that, whatever the stage of development, reactive neuronal cells are included in the well-defined large type A population. The possibility that neuronal CA expression is a reliable marker of the 'functional activity' of the proprioceptive neurons in mammals is discussed. The late development expression of the enzyme (after target innervation) raises the possibility of a regulation of the CA phenotype by neuron-target interactions.
Keywords
Animals, Carbonic Anhydrases, Embryonic and Fetal Development, Ganglia, Spinal, Mice, Neurons, Afferent, Phenotype
Pubmed
Create date
24/01/2008 15:55
Last modification date
20/08/2019 15:53
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