The role of the inflammasome in nonmyeloid cells.

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Serval ID
serval:BIB_D39C24EC14B8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of the inflammasome in nonmyeloid cells.
Journal
Journal of Clinical Immunology
Author(s)
Yazdi A.S., Drexler S.K., Tschopp J.
ISSN
1573-2592[electronic], 0271-9142[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
30
Number
5
Pages
623-627
Language
english
Abstract
Inflammasomes are cytosolic multiprotein complexes that can proteolytically activate caspase-1. Activated caspase-1 is needed for the maturation and secretion of interleukin (IL)-1beta and IL-18. In the past decade, there has been tremendous progress in our knowledge of inflammasome function and IL-1 signaling, mainly in cells of the innate immune system, such as monocytes, macrophages, neutrophils, and dendritic cells. Because nonimmune cells, including keratinocytes, synovial cells, or astrocytes, can form an interface between the body and the environment or a defined compartment (brain, joint), they are important guardians for the detection of danger signals and the consecutive initiation of an inflammatory response. They are present in anatomical compartments that are less accessible to myeloid cells and thus can fulfill tasks usually performed by residential macrophages. This review focuses on recent progress in our understanding of the processing and functional role of IL-1 in epithelial, mesenchymal, and neuronal cells and in conditions such as tissue repair.
Keywords
Inflammasome, nonmyeloid cells, interleukin
Pubmed
Web of science
Open Access
Yes
Create date
07/09/2010 15:21
Last modification date
01/10/2019 6:19
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