Review of the impact of MALDI-TOF MS in public health and hospital hygiene, 2018.

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Ressource 1Download: eurosurv-24-4-9.pdf (573.11 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D38550346899
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Review of the impact of MALDI-TOF MS in public health and hospital hygiene, 2018.
Journal
Euro surveillance
Author(s)
Rodríguez-Sánchez B., Cercenado E., Coste A.T., Greub G.
ISSN
1560-7917 (Electronic)
ISSN-L
1025-496X
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
24
Number
4
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
IntroductionMALDI-TOF MS represents a new technological era for microbiology laboratories. Improved sample processing and expanded databases have facilitated rapid and direct identification of microorganisms from some clinical samples. Automated analysis of protein spectra from different microbial populations is emerging as a potential tool for epidemiological studies and is expected to impact public health.AimTo demonstrate how implementation of MALDI-TOF MS has changed the way microorganisms are identified, how its applications keep increasing and its impact on public health and hospital hygiene.MethodsA review of the available literature in PubMED, published between 2009 and 2018, was carried out.ResultsOf 9,709 articles retrieved, 108 were included in the review. They show that rapid identification of a growing number of microorganisms using MALDI-TOF MS has allowed for optimisation of patient management through prompt initiation of directed antimicrobial treatment. The diagnosis of Gram-negative bacteraemia directly from blood culture pellets has positively impacted antibiotic streamlining, length of hospital stay and costs per patient. The flexibility of MALDI-TOF MS has encouraged new forms of use, such as detecting antibiotic resistance mechanisms (e.g. carbapenemases), which provides valuable information in a reduced turnaround time. MALDI-TOF MS has also been successfully applied to bacterial typing.ConclusionsMALDI-TOF MS is a powerful method for protein analysis. The increase in speed of pathogen detection enables improvement of antimicrobial therapy, infection prevention and control measures leading to positive impact on public health. For antibiotic susceptibility testing and bacterial typing, it represents a rapid alternative to time-consuming conventional techniques.
Keywords
Anti-Bacterial Agents/therapeutic use, Bacteremia/diagnosis, Bacteremia/drug therapy, Bacteremia/microbiology, Bacteria/classification, Bacteria/drug effects, Bacteria/isolation & purification, Drug Resistance, Microbial, Humans, Hygiene, Microbial Sensitivity Tests/methods, Microbiological Techniques/methods, Mycological Typing Techniques, Public Health, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods, MALDI-TOF MS, Mass Spectrometry, antibiotic resistance mechanisms, antibiotic use, hygiene, microorganism identification, mycobacteria, typing
Pubmed
Web of science
Open Access
Yes
Create date
18/02/2019 16:34
Last modification date
13/08/2020 5:21
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