Morphological, molecular, and prognostic aspects of gastric endocrine tumors.

Details

Serval ID
serval:BIB_D380B452EDBD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Morphological, molecular, and prognostic aspects of gastric endocrine tumors.
Journal
Microscopy Research and Technique
Author(s)
Solcia E., Rindi G., Larosa S., Capella C.
ISSN
1059-910X (Print)
ISSN-L
1059-910X
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
48
Number
6
Pages
339-348
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
This paper aims at describing the neuroendocrine cell growths of the gastric mucosa and their pathogenesis. In the corpus-fundus mucosa, gastric neuroendocrine nontumor growths are mostly represented by hyperplastic and, more rarely, dysplastic enterochromaffin-like (ECL) cell changes, while hyperplasia of gastrin-producing (G) cells and, rarely, of somatostatin-producing (D) cells are reported in the antral mucosa. The large majority of gastric neuroendocrine tumors is made by benign, gastrin-dependent, well-differentiated ECL cell growths arising in a background of chronic atrophic gastritis (type I) or, more rarely, associated with type I multiple endocrine neoplasia (MEN I) and Zollinger-Ellison (ZE) syndromes (type II). Rare, aggressive, frequently metastatic, well-differentiated gastric neuroendocrine tumors are gastrin-independent and arise as sporadic lesions in the absence of specific gastric pathology (type III). Poorly differentiated neuroendocrine carcinomas (PDEC) are rare, highly aggressive carcinomas. A central role for gastrin is postulated in the pathogenesis of well-differentiated type I and II ECL cell tumors with different possible genetic mechanisms. A more complex genetic background, independent of gastrin and possibly implicating altered function or mutation of p53 and other genes is highly suspected for the development of aggressive type III ECL cell carcinomas and PDECs.
Keywords
Gastric Mucosa/pathology, Humans, Neuroendocrine Tumors/genetics, Neuroendocrine Tumors/mortality, Prognosis, Stomach Neoplasms/genetics, Stomach Neoplasms/mortality
Pubmed
Web of science
Create date
07/09/2016 8:37
Last modification date
20/08/2019 15:53
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