Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2.

Details

Serval ID
serval:BIB_D332BE38D258
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2.
Journal
Neuroimage
Author(s)
Tan G.C., Doke T.F., Ashburner J., Wood N.W., Frackowiak R.S.
ISSN
1095-9572[electronic], 1053-8119[linking]
Publication state
Published
Issued date
2010
Volume
53
Number
3
Pages
1030-1042
Language
english
Abstract
Recent genetic studies have implicated a number of candidate genes in the pathogenesis of Autism Spectrum Disorder (ASD). Polymorphisms of CNTNAP2 (contactin-associated like protein-2), a member of the neurexin family, have already been implicated as a susceptibility gene for autism by at least 3 separate studies. We investigated variation in white and grey matter morphology using structural MRI and diffusion tensor imaging. We compared volumetric differences in white and grey matter and fractional anisotropy values in control subjects characterised by genotype at rs7794745, a single nucleotide polymorphism in CNTNAP2. Homozygotes for the risk allele showed significant reductions in grey and white matter volume and fractional anisotropy in several regions that have already been implicated in ASD, including the cerebellum, fusiform gyrus, occipital and frontal cortices. Male homozygotes for the risk alleles showed greater reductions in grey matter in the right frontal pole and in FA in the right rostral fronto-occipital fasciculus compared to their female counterparts who showed greater reductions in FA of the anterior thalamic radiation. Thus a risk allele for autism results in significant cerebral morphological variation, despite the absence of overt symptoms or behavioural abnormalities. The results are consistent with accumulating evidence of CNTNAP2's function in neuronal development. The finding suggests the possibility that the heterogeneous manifestations of ASD can be aetiologically characterised into distinct subtypes through genetic-morphological analysis.
Keywords
Magnetic resonance imaging (MRI), Voxel-based morphometry (VBM), Diffusion tensor imaging (DTI), CNTNAP2, Autism, Endophenotype, voxel-based morphometry, fusiform face area, x-linked genes, spectrum disorder, brain structure, neurexin superfamily, functioning autism, asperger-syndrome, myelinated axons, k+ channels
Pubmed
Web of science
Open Access
Yes
Create date
13/10/2010 13:28
Last modification date
20/08/2019 15:53
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