Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia.

Details

Serval ID
serval:BIB_D2C26234108D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia.
Journal
Cancer Genetics and Cytogenetics
Author(s)
Wehrli L.A., Braun J., Buetti L.N., Hagleitner N., Hengartner H., Kühne T., Lüer S., Ozsahin H., Popovic M.B., Niggli F.K., Betts D.R., Bourquin J.P.
ISSN
1873-4456[electronic]
Publication state
Published
Issued date
2009
Volume
189
Number
1
Pages
29-36
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Karyotype analysis of acute lymphoblastic leukemia (ALL) at diagnosis has provided valuable prognostic markers for treatment stratification. However, reports of cytogenetic studies of relapsed ALL samples are limited. We compared the karyotypes from 436 nonselected B-cell precursor ALL patients at initial diagnosis and of 76 patients at first relapse. We noticed a relative increase of karyotypes that did not fall into the classic ALL cytogenetic subgroups (high hyperdiploidy, t(12;21), t(9;22), 11q23, t(1;19), <45 chromosomes) in a group of 29 patients at relapse (38%) compared to 130 patients at presentation (30%). Non-classical cytogenetic aberrations in these 29 patients were mostly found on chromosomes 1, 2, 7, 9, 13, 14, and 17. We also describe six rare reciprocal translocations, three of which involved 14q32. The most frequent abnormalities were found in 9p (12/29 cases) and were associated with a marked decrease in the duration of the second remission, but not of the probability of 10-year event-free survival after relapse treatment. From 29 patients with non-classical cytogenetic aberrations, only 8 (28%) had been stratified to a high risk-arm on the first treatment protocol, suggesting that this subgroup might benefit from the identification of new prognostic markers in future studies.
Keywords
Acute Disease, Adolescent, Child, Child, Preschool, Chromosome Aberrations, Female, Humans, Infant, Karyotyping, Male, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/prevention & control, Recurrence, Translocation, Genetic, Treatment Outcome
Pubmed
Web of science
Create date
09/02/2010 16:20
Last modification date
20/08/2019 15:52
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