Intraluminal pressure modulates the magnitude and the frequency of induced vasomotion in rat arteries

Details

Serval ID
serval:BIB_D270080FFB0D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intraluminal pressure modulates the magnitude and the frequency of induced vasomotion in rat arteries
Journal
Journal of Vascular Research
Author(s)
Achakri  H., Stergiopulos  N., Hoogerwerf  N., Hayoz  D., Brunner  H. R., Meister  J. J.
ISSN
1018-1172 (Print)
Publication state
Published
Issued date
08/1995
Volume
32
Number
4
Pages
237-46
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul-Aug
Abstract
Arterial vasomotion and its relation to intraluminal pressure were investigated in vitro in isolated rat arteries. Femoral arteries (mean diameter = 768.2 +/- 25 microns, n = 5) and mesenteric arteries (mean diameter = 393.4 +/- 32 microns, n = 5) were used in this study. Arterial segments were excised, mounted on microcannulas and perfused with Tyrode's solution at a constant flow (100 microliters/min). After equilibration, intraluminal pressure was stepwise changed from 0 to 120 mm Hg. The changes in the outer diameter of the vessels were measured continuously over a period of 4 h after the equilibration. Vasomotion was induced by constrictor agonists (norepinephrine 10(-6) M for mesenteric arteries and norepinephrine 10(-6) M + Bay K8644 10(-7) M for femoral arteries) and was maintained only in the presence of the above-mentioned drugs. Both vasomotion magnitude and frequency are modulated by pressure. Vasomotion frequency increases with pressure increase. When intraluminal pressure varied between 0 and 120 mm Hg, vasomotion frequency varied between 0.19 and 0.49 Hz for mesenteric arteries and between 0.04 and 0.23 Hz for femoral arteries. Thus, vasomotion frequency differed clearly between the two vessel types. Vasomotion amplitude shows a biphasic relationship with a maximum occurring at about 40 mm Hg for mesenteric arteries and 50 mm Hg for femoral arteries. Based on these findings, it is hypothesized that vasomotion amplitude relates to the active mechanical properties of the artery and, in particular, to its contractile capacity.
Keywords
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology Animals Arteries/*physiology Blood Pressure/*physiology Calcium/pharmacology Femoral Artery/physiology Mesenteric Arteries/physiology Muscle Contraction Norepinephrine/pharmacology Rats Rats, Wistar Vasomotor System/*physiology
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 15:52
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