Evaluation of the compliance with recommended procedures in newborns exposed to HBsAg-positive mothers: a multicenter collaborative study.

Details

Serval ID
serval:BIB_D250DA0EF911
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of the compliance with recommended procedures in newborns exposed to HBsAg-positive mothers: a multicenter collaborative study.
Journal
Pediatric Infectious Disease Journal
Author(s)
Heininger U., Vaudaux B., Nidecker M., Pfister R.E., Posfay-Barbe K.M., Bachofner M., Hoigné I., Gnehm H.E.
ISSN
1532-0987[electronic], 0891-3668[linking]
Publication state
Published
Issued date
2010
Volume
29
Number
3
Pages
248-250
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
BACKGROUND: Maternal-infant transmission of hepatitis B virus (HBV) during birth carries a high risk for chronic HBV infection in infants with frequent subsequent development of chronic disease. This can be efficiently prevented by early immunization of exposed newborns. The purpose of this study was to determine the compliance with official recommendations for prevention of perinatal HBV transmission in hepatitis B surface antigen (HBsAg) exposed infants. METHODS: Records of pregnant women at 4 sites in Switzerland, admitted for delivery in 2005 and 2006, were screened for maternal HBsAg testing. In HBsAg-exposed infants, recommended procedures (postnatal active and passive immunization, completion of immunization series, and serological success control) were checked. RESULTS: Of 27,131 women tested for HBsAg, 194 (0.73%) were positive with 196 exposed neonates. Of these neonates, 143 (73%) were enrolled and 141 (99%) received simultaneous active and passive HBV immunization within 24 hours of birth. After discharge, the HBV immunization series was completed in 83%. Only 38% of children were tested for anti-HBs afterwards and protective antibody values (>100 U/L) were documented in 27% of the study cohort. No chronically infected child was identified. Analysis of hospital discharge letters revealed significant quality problems. CONCLUSIONS: Intensified efforts are needed to improve the currently suboptimal medical care in HBsAg-exposed infants. We propose standardized discharge letters, as well as reminders to primary care physicians with precise instructions on the need to complete the immunization series in HBsAg-exposed infants and to evaluate success by determination of anti-HBs antibodies after the last dose.
Keywords
Female, Guideline Adherence/statistics & numerical data, Health Services Research, Hepatitis B/prevention & control, Hepatitis B/transmission, Hepatitis B Surface Antigens/blood, Hepatitis B Vaccines/administration & dosage, Humans, Immunization, Passive/utilization, Infant, Newborn, Infectious Disease Transmission, Vertical/prevention & control, Male, Mothers, Pregnancy, Switzerland, Vaccination/utilization
Pubmed
Web of science
Create date
28/06/2010 16:51
Last modification date
20/08/2019 15:52
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