Long diagnostic delay in Crohn's disease is associated with complicated disease course and increased operation rate


Serval ID
Inproceedings: an article in a conference proceedings.
Publication sub-type
Poster: Summary – with images – on one page of the results of a researche project. The summaries of the poster must be entered in "Abstract" and not "Poster".
Long diagnostic delay in Crohn's disease is associated with complicated disease course and increased operation rate
Title of the conference
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society of Visceral Surgery, Swiss Association of the Study of the Liver and Swiss Society of Clinical Nutrition
Schoepfer A.M., Dehlavi M.A., Pittet V., Fournier N., Safroneeva E., Rogler G., Vavricka SR.
Interlaken, Switzerland, September 20-21, 2012
Publication state
Issued date
Swiss Medical Weekly
Background and Aims: The impact of d iagnostic delay ( a
period from appearance of f irst s ymptoms t o diagnosis) o n the
clinical c ourse o f Crohn's disease (CD) i s unknown. W e
examined whether length of d iagnostic delay a ffects d isease
outcome. Methods: Data from the Swiss IBD cohort study were
analyzed. T he frequencies of o ccurrence of b owel s tenoses,
internal fistulas, perianal f istulas, and CD-related surgery at
distinct i ntervals a fter C D diagnosis (0 - < 2 , 2 - < 6,  6
years) were c ompared f or g roups o f patients w ith different
length of d iagnostic delay. Results: T he data from a g roup o f
200 CD patients with long diagnostic delay (> 24 months, 76th -
100th p ercentile) were c ompared to t hose from a group of 4 61
patients with a short diagnostic delay ( within 9 months, 1st -
50th p ercentile). T reatment r egimens d id n ot d iffer between t he
two groups. Two years following diagnosis, p atients with long
diagnostic delay presented more frequently with bowel stenoses
(25% vs. 13.1%, p = 0.044), internal fistulas (10% vs. 2%, p =
0.018), perianal f istulas ( 20% vs. 8 .1%, p = 0.023) a nd more
frequently underwent intestinal surgery (15% vs. 5 .1%, p =
0.024) t han patients with short diagnostic delay. Intestinal
surgery was a lso m ore frequently p erformed  6 y ears after
diagnosis in t he group with long d iagnostic delay ( 56.2% vs.
42.3%, p = 0.005) w hen compared to t he g roup with short
diagnostic delay. Conclusions: L ong diagnostic delay i s
associated with worse o utcome c haracterized by t he
development o f increased bowel damage, n ecessitating more
frequently operations in t he years following CD d iagnosis.
Efforts should be undertaken to shorten the diagnostic delay.
Create date
14/02/2013 16:31
Last modification date
20/08/2019 15:52
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