Circulating miRNAs: a new generation of anti-doping biomarkers

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Ressource 1Download: serval:BIB_D1E1A08E5864.P001 (255.33 [Ko])
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Version: author
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_D1E1A08E5864
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circulating miRNAs: a new generation of anti-doping biomarkers
Journal
Analytical and Bioanalytical Chemistry
Author(s)
Leuenberger N., Robinson N., Saugy M.
ISSN
1618-2650 (Electronic)
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
405
Number
30
Pages
9617-9623
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that regulate a variety of biological processes. Cell-free miRNAs detected in blood plasma are used as specific and sensitive markers of physiological processes and some diseases. Circulating miRNAs are highly stable in body fluids, for example plasma. Therefore, profiles of circulating miRNAs have been investigated for potential use as novel, non-invasive anti-doping biomarkers. This review describes the biological mechanisms underlying the variation of circulating miRNAs, revealing that they have great potential as a new class of biomarker for detection of doping substances. The latest developments in extraction and profiling technology, and the technical design of experiments useful for anti-doping, are also discussed. Longitudinal measurements of circulating miRNAs in the context of the athlete biological passport are proposed as an efficient strategy for the use of these new markers. The review also emphasizes potential challenges for the translation of circulating miRNAs from research into practical anti-doping applications.
Pubmed
Web of science
Open Access
Yes
Create date
16/12/2013 11:48
Last modification date
01/10/2019 7:19
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