Comparison of hospital-wide and unit-specific cumulative antibiograms in hospital- and community-acquired infection.

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Serval ID
serval:BIB_D186294804C4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of hospital-wide and unit-specific cumulative antibiograms in hospital- and community-acquired infection.
Journal
Infection
Author(s)
Lamoth F., Wenger A., Prod'hom G., Vallet Y., Plüss-Suard C., Bille J., Zanetti G.
ISSN
1439-0973[electronic], 0300-8126[linking]
Publication state
Published
Issued date
2010
Volume
38
Number
4
Pages
249-253
Language
english
Abstract
BACKGROUND: Empirical antibacterial therapy in hospitals is usually guided by local epidemiologic features reflected by institutional cumulative antibiograms. We investigated additional information inferred by aggregating cumulative antibiograms by type of unit or according to the place of acquisition (i.e. community vs. hospital) of the bacteria.
MATERIALS AND METHODS: Antimicrobial susceptibility rates of selected pathogens were collected over a 4-year period in an university-affiliated hospital. Hospital-wide antibiograms were compared with those selected by type of unit and sampling time (<48 or >48 h after hospital admission).
RESULTS: Strains isolated >48 h after admission were less susceptible than those presumably arising from the community (<48 h). The comparison of units revealed significant differences among strains isolated >48 h after admission. When compared to hospital-wide antibiograms, susceptibility rates were lower in the ICU and surgical units for Escherichia coli to amoxicillin-clavulanate, enterococci to penicillin, and Pseudomonas aeruginosa to anti-pseudomonal beta-lactams, and in medical units for Staphylococcus aureus to oxacillin. In contrast, few differences were observed among strains isolated within 48 h of admission.
CONCLUSIONS: Hospital-wide antibiograms reflect the susceptibility pattern for a specific unit with respect to community-acquired, but not to hospital-acquired strains. Antibiograms adjusted to these parameters may be useful in guiding the choice of empirical antibacterial therapy.
Keywords
Antibiogram, Bacterial sensitivity tests, Hospital units, Nosocomial infections, Antibiotic resistance
Pubmed
Web of science
Open Access
Yes
Create date
18/08/2010 15:07
Last modification date
01/10/2019 7:19
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