Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.

Details

Serval ID
serval:BIB_D17A1AB4E7D7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling.
Journal
Journal of Biological Chemistry
Author(s)
Plasari G., Edelmann S., Högger F., Dusserre Y., Mermod N., Calabrese A.
ISSN
1083-351X[electronic], 0021-9258[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
285
Number
44
Pages
34115-34125
Language
english
Abstract
Skin appendages such as teeth and hair share several common signaling pathways. The nuclear factor I C (NFI-C) transcription factor has been implicated in tooth development, but a potential role in hair growth had not been assessed. In this study we found that NFI-C regulates the onset of the hair growth cycle. NFI-C(-/-) mice were delayed in the transition from the telogen to anagen phase of the hair follicle cycle after either experimental depilation or spontaneous hair loss. Lack of NFI-C resulted in delayed induction of the sonic hedgehog, Wnt5a, and Lef1 gene expression, which are key regulators of the hair follicle growth initiation. NFI-C(-/-) mice also showed elevated levels of transforming growth factor β1 (TGF-β1), an inhibitor of keratinocyte proliferation, and of the cell cycle inhibitor p21 at telogen. Reduced expression of Ki67, a marker of cell proliferation, was noted at the onset of anagen, indicating impaired activation of the hair progenitor cells. These findings implicate NFI-C in the repression of TGF-β1 signaling during telogen stage, resulting in the delay of progenitor cell proliferation and hair follicle regeneration in NFI-C-deficient mice. Taken together with prior observations, these findings also designate NFI-C as a regulator of adult progenitor cell proliferation and of postnatal tissue growth or regeneration.
Keywords
Animals, Cell Proliferation, Hair/physiology, Hair Follicle/metabolism, Immunohistochemistry/methods, Lymphoid Enhancer-Binding Factor 1/biosynthesis, Mice, Mice, Knockout, Mice, Transgenic, NFI Transcription Factors/chemistry, Phenotype, Signal Transduction, Stem Cells/cytology, Transforming Growth Factor beta/metabolism, Wnt Proteins/biosynthesis
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2011 16:03
Last modification date
09/05/2019 1:36
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