Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.

Details

Serval ID
serval:BIB_D1618479457A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.
Journal
Cell Metabolism
Author(s)
Jornayvaz F.R., Shulman G.I.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
15
Number
5
Pages
574-584
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this relationship are unknown, hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked to hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of protein kinase Cε as the mechanism responsible for NAFLD-associated hepatic insulin resistance seen in obesity, type 2 diabetes, and lipodystrophy.
Keywords
Animals, Diabetes Mellitus, Type 2/enzymology, Diabetes Mellitus, Type 2/metabolism, Diglycerides/metabolism, Fatty Liver/enzymology, Fatty Liver/metabolism, Humans, Insulin Resistance/physiology, Liver/metabolism, Mice, Non-alcoholic Fatty Liver Disease, Protein Kinase C-epsilon/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
10/09/2015 12:19
Last modification date
20/08/2019 15:51
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