Fibrose superficielle radio-induite et TGF-beta 1 [Radiation-induced superficial fibrosis and TGF-alpha 1]

Details

Serval ID
serval:BIB_D14B5886FD85
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Fibrose superficielle radio-induite et TGF-beta 1 [Radiation-induced superficial fibrosis and TGF-alpha 1]
Journal
Cancer radiotherapie
Author(s)
Martin M., Delanian S., Sivan V., Vozenin-Brotons M.C., Reisdorf P., Lawrence D., Lefaix J.L.
ISSN
1278-3218 (Print)
ISSN-L
1278-3218
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
4
Number
5
Pages
369-384
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, which has been described in various tissues, including the lung, liver, kidney and skin. This review presents different aspects of superficial radiation-induced fibrosis, such as clinical observations, histological changes, cellular and molecular regulations, and medical management. Recent evidence on the critical role played by TGF-beta 1 in the initiation, development and persistence of fibrosis are discussed, as well as the possibility that this cytokine may constitute a specific target for antifibrotic agents.

Keywords
Animals, Dose-Response Relationship, Radiation, Fibroblasts/pathology, Fibroblasts/radiation effects, Fibrosis/pathology, Humans, Radiation Injuries/pathology, Radiation Injuries/prevention & control, Transforming Growth Factor beta/antagonists & inhibitors, Transforming Growth Factor beta/physiology, Transforming Growth Factor beta1
Pubmed
Create date
27/04/2018 15:13
Last modification date
20/08/2019 15:51
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