Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia.

Details

Serval ID
serval:BIB_D13A5ABEE84C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia.
Journal
Nature
Author(s)
Dolan R.J., Fletcher P., Frith C.D., Friston K.J., Frackowiak R.S., Grasby P.M.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Publication state
Published
Issued date
1995
Volume
378
Number
6553
Pages
180-182
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Dopaminergic dysregulation remains an empirical cornerstone for theories concerning the causation of schizophrenia. Evidence for a dopamine system dysfunction in schizophrenia includes the psychosis-inducing effects of dopaminergic agonists and the antipsychotic potency of dopaminergic antagonists. Here we use positron emission tomography (PET) to examine the regulatory role of dopamine on cortical function in normal subjects and unmedicated schizophrenic patients. Using a factorial experimental design, we compared the effect of dopaminergic manipulation with apomorphine on a neural response to a cognitive task. In the schizophrenic patients, relative to controls, an impaired cognitive activation of the anterior cingulate cortex was significantly modulated by a manipulation of dopaminergic neurotransmission. Thus, after apomorphine, the schizophrenic subjects displayed a significantly enhanced cognitive activation of the anterior cingulate cortex relative to the controls. These data provide in vivo evidence that an impaired cognitive-task-induced activation of the anterior cingulate cortex in schizophrenic patients can be significantly modulated by a dopaminergic manipulation.
Keywords
Adult, Apomorphine/pharmacology, Cerebrovascular Circulation, Cognition/drug effects, Dopamine/metabolism, Dopamine Agonists/pharmacology, Gyrus Cinguli/blood supply, Gyrus Cinguli/drug effects, Humans, Male, Schizophrenia/metabolism, Schizophrenia/physiopathology, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 19:31
Last modification date
20/08/2019 15:51
Usage data