A specific template-assembled peptidic agonist for the angiotensin II receptor subtype 2 (AT2) and its effect on inferior olivary neurones

Details

Serval ID
serval:BIB_D0F0FF02A368
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A specific template-assembled peptidic agonist for the angiotensin II receptor subtype 2 (AT2) and its effect on inferior olivary neurones
Journal
European Journal of Biochemistry
Author(s)
Grouzmann  E., Felix  D., Imboden  H., Razaname  A., Mutter  M.
ISSN
0014-2956 (Print)
Publication state
Published
Issued date
11/1995
Volume
234
Number
1
Pages
44-9
Notes
Journal Article --- Old month value: Nov 15
Abstract
We synthesized a molecule composed of two angiotensin II 4-8 pentapeptide fragments attached to a carrier molecule (TA), according to the template-assembled synthetic proteins concept. This molecule was investigated for receptor binding on angiotensin type-1 and type-2 receptors (AT1 and AT2) and its biological activity was determined by iontophoretic experiments on neurones of the inferior olive (ION) that express only AT2 receptors. TA binds exclusively to the AT2 receptor and mediates an agonistic angiotensin-II effect on the ION. TA is the first agonist available to study the direct stimulation of AT2 receptors.
Keywords
Amino Acid Sequence Angiotensin I/metabolism Angiotensins/*pharmacology Animals Calcium/metabolism Iontophoresis Molecular Sequence Data Olivary Nucleus/*drug effects Peptide Fragments/*pharmacology Rats Rats, Sprague-Dawley Receptors, Angiotensin/*agonists/metabolism Templates, Genetic
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 10:55
Last modification date
20/08/2019 15:51
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