Platforms for high-throughput screening of Wnt/Frizzled antagonists.

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Version: Final published version
Serval ID
serval:BIB_D0EAC465E0F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Platforms for high-throughput screening of Wnt/Frizzled antagonists.
Journal
Drug Discovery Today
Author(s)
Koval A., Katanaev V.L.
ISSN
1878-5832 (Electronic)
ISSN-L
1359-6446
Publication state
Published
Issued date
2012
Volume
17
Number
23-24
Pages
1316-1322
Language
english
Notes
Publication types: Journal Article
WOS Document Type: Review
Abstract
Signaling cascades initiated by Wnt lipoglycoproteins and their receptors of the Frizzled family regulate many aspects of animal development and physiology. Improper activation of this signaling promotes carcinogenic transformation and metastasis. Development of agents blocking the Wnt-Frizzled signaling is of prime interest for drug discovery. Despite certain progress no such agents are as yet brought to the market or even to clinical trials. One reason for these delays might be the use of suboptimal readout assays. In this article we overview existing and developing assay platforms to screen for Wnt-Frizzled antagonists. Among those, G protein-activating assays built on the emerging GPCR properties of Frizzleds are highlighted.
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2013 18:20
Last modification date
20/10/2020 10:12
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