Conflicts of interest in clinical practice: lessons learned from cardiovascular medicine.
Details
Serval ID
serval:BIB_D0DFE6D9EABA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Conflicts of interest in clinical practice: lessons learned from cardiovascular medicine.
Journal
European journal of cardio-thoracic surgery
Working group(s)
INTEGRITTY, and with the endorsement of the Latin American Association of Cardiac and Endovascular Surgery (LACES), the Latin European Alliance of Cardiovascular Surgical Societies (LEACSS), the Brazilian Society of Cardiovascular Surgery (BSCVS), the French Society of Thoracic and Cardio-Vascular Surgery (SFCTCV), the Italian Society for Cardiac Surgery (SICCH), the Mexican College of Cardiovascular and Thoracic Surgery, the Portuguese Society of Cardiac Thoracic and Vascular Surgery (SPCCTV) and the Spanish Cardiovascular and Endovascular Society (SECCE)
Contributor(s)
Albuquerque A., Almeida R., Anselmi A., Barili F., Beurtheret S., Biondi-Zoccai G., Boden W., Borger M., Brophy J., Buttiglione G., Dayan V., De Caterina R., de la Cuesta M., Faxon D., Firstenberg M., Garcia-Villareal O., Gomes W., Heuts S., Kaul S., Kawczynski M., Mandrola J., Cuartas M.M., Misfeld M., Musumeci F., Parolari A., Quintana E., Redberg R., Riad R., Stuart J.R., Ronco D., Uva M.S., Taggart D., Tomasi J., Verhoye J.P., Yan T., Zenati M.
ISSN
1873-734X (Electronic)
ISSN-L
1010-7940
Publication state
Published
Issued date
02/09/2024
Peer-reviewed
Oui
Volume
66
Number
3
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
Cardiovascular diseases represent a major burden worldwide, and clinical trials are critical to define treatment improvements. Since various conflicts of interest (COIs) may influence trials at multiple levels, cardiovascular research represents a paradigmatic example to analyze their effects and manage them effectively to re-establish the centrality of evidence-based medicine.Despite the manifest role of industry, COIs may differently affect both sponsored and non-sponsored studies in many ways. COIs influence may start from the research question, data collection and adjudication, up to result reporting, including the spin phenomenon. Outcomes and endpoints (especially composite) choice and definitions also represent potential sources for COIs interference. Since large randomized controlled trials significantly influence international guidelines, thus impacting also clinical practice, their critical assessment for COIs is mandatory. Despite specific protocols aimed to mitigate COI influence, even scientific societies and guideline panels may not be totally free from COIs, negatively affecting their accountability and trustworthiness.Shared rules, awareness of COI mechanisms and transparency with external data access may help promoting evidence-based research and mitigate COIs impact. Managing COIs effectively should preserve public trust in the cardiovascular profession without compromising the positive relationships between investigators and industry.
Keywords
Conflict of Interest, Humans, Cardiovascular Diseases/therapy, Cardiology/ethics, Biomedical Research/ethics, Evidence-Based Medicine, Research Support as Topic/ethics, Aortic valve replacement, Cardiovascular research, Conflicts of interest, Coronary revascularization, Randomized controlled trials, Transcatheter aortic valve implantation
Pubmed
Create date
27/09/2024 15:50
Last modification date
28/09/2024 7:09