DNA damage among wood workers assessed with the comet assay

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_D0B87D4DF89A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
DNA damage among wood workers assessed with the comet assay
Journal
Environmental Health Insights
Author(s)
Bruschweiler Evin D., Wild Pascal, Huynh Cong Khanh, Savova-Bianchi Dessislava, Danuser Brigitta, Hopf Nancy B.
ISSN
1178-6302 (Print)
ISSN-L
1178-6302
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
10
Pages
105-112
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Exposure to wood dust, a human carcinogen, is common in wood-related industries, and millions of workers are occupationally exposed to wood dust worldwide. The comet assay is a rapid, simple, and sensitive method for determining DNA damage. The objective of this study was to investigate the DNA damage associated with occupational exposure to wood dust using the comet assay (peripheral blood samples) among nonsmoking wood workers (n = 31, furniture and construction workers) and controls (n = 19). DNA damage was greater in the group exposed to composite wood products compared to the group exposed to natural woods and controls (P < 0.001). No difference in DNA damage was observed between workers exposed to natural woods and controls (P = 0.13). Duration of exposure and current dust concentrations had no effect on DNA damage. In future studies, workers' exposures should include cumulative dust concentrations and exposures originating from the binders used in composite wood products.
Keywords
Wood, Dust, Occupational Exposure, DNA Damage, Comet Assay, DNA damage, comet assay, occupational exposure, wood dust
Pubmed
Web of science
Open Access
Yes
Create date
14/11/2016 11:42
Last modification date
20/08/2019 16:50
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