Classifying dementia progression using microbial profiling of saliva.

Details

Serval ID
serval:BIB_D08E4B7845AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Classifying dementia progression using microbial profiling of saliva.
Journal
Alzheimer's & dementia
Author(s)
Bathini P., Foucras S., Dupanloup I., Imeri H., Perna A., Berruex J.L., Doucey M.A., Annoni J.M., Auber Alberi L.
ISSN
2352-8729 (Print)
ISSN-L
2352-8729
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
12
Number
1
Pages
e12000
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
There is increasing evidence linking periodontal infections to Alzheimer's disease (AD). Saliva sampling can reveal information about the host and pathogen interactions that can inform about physiological and pathological brain states.
A cross-sectional cohort of age-matched participants (78) was segmented according to their chemosensory (University of Pennsylvania Smell Identification Test; UPSIT) and cognitive scores (Mini-Mental State Exam; MMSE and clinical dementia rating; CDR). Mid-morning saliva was sampled from each participant and processed for microbiome composition and cytokine analysis. Linear discriminant analysis (LDA) was used to unravel specific changes in microbial and immunological signatures and logistic regression analysis (LRA) was employed to identify taxa that varied in abundance among patient groups.
Using olfaction we distinguish in the cognitively normal population a segment with high chemosensory scores (CNh, 27) and another segment with chemosensory scores (CNr, 16) as low as mild cognitive impairment (MCI, 21) but higher than the AD group (17). We could identify stage-specific microbial signatures changes but no clearly distinct cytokine profiles. Periodontal pathogen species as Filifactor villosus decline with the increasing severity of AD, whereas opportunistic oral bacteria such as Leptotrichia wadei show a significant enrichment in MCI.
The salivary microbiome indicates stage-dependent changes in oral bacteria favoring opportunistic species at the expense of periodontal bacteria, whereas the inflammatory profiles remain mainly unchanged in the sampled population.
Keywords
Alzheimer's disease, cytokines, olfaction, oral microbiome
Pubmed
Web of science
Open Access
Yes
Create date
17/08/2020 10:29
Last modification date
13/02/2024 8:24
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