Streptococcus tigurinus is highly virulent in a rat model of experimental endocarditis.
Details
Serval ID
serval:BIB_D0834021ED45
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Streptococcus tigurinus is highly virulent in a rat model of experimental endocarditis.
Journal
International Journal of Medical Microbiology
ISSN
1618-0607 (Electronic)
ISSN-L
1438-4221
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
303
Number
8
Pages
498-504
Language
english
Abstract
Streptococcus tigurinus is responsible for systemic infections in humans including infective endocarditis. We investigated whether the invasive trait of S. tigurinus in humans correlated with an increased ability to induce IE in rats. Rats with catheter-induced aortic vegetations were inoculated with 10⁴ CFU/ml of either of four S. tigurinus strains AZ_3a(T), AZ_4a, AZ_8 and AZ_14, isolated from patients with infective endocarditis or with the well known IE pathogen Streptococcus gordonii (Challis). Aortic infection was assessed after 24 h. S. tigurinus AZ_3a(T), AZ_4a and AZ_14 produced endocarditis in ≥80% of rats whereas S. gordonii produced endocarditis in only 33% of animals (P<0.05). S. tigurinus AZ_8 caused vegetation infection in 56% of the animals. The capacity of S. tigurinus to induce aortic infection was not related to their ability to bind extracellular matrix proteins (fibrinogen, fibronectin or collagen) or to trigger platelet aggregation. However, all S. tigurinus isolates showed an enhanced resistance to phagocytosis by macrophages and two of them had an increased ability to enter endothelial cells, key attributes of invasive streptococcal species.
Pubmed
Web of science
Create date
29/01/2014 11:45
Last modification date
20/08/2019 16:50