Corticotropin-releasing activity of the renin-angiotensin system peptides in rat and in man

Details

Serval ID
serval:BIB_D07A0F4F4872
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Corticotropin-releasing activity of the renin-angiotensin system peptides in rat and in man
Journal
Neuroendocrinology
Author(s)
Gaillard  R. C., Favrod-Coune  C. A., Capponi  A. M., Muller  A. F.
ISSN
0028-3835 (Print)
Publication state
Published
Issued date
12/1985
Volume
41
Number
6
Pages
511-7
Notes
Comparative Study
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
In this study we investigated in the rat the binding and corticotropin-releasing factor (CRF) activity of various constituents of the renin-angiotensin system and the possible angiotensin II receptor changes following procedures known to alter plasma renin activity. We investigated also the CRF activity of angiotensin II in vitro and in vivo in humans. The CRF activity of peptides was studied by their ability to stimulate ACTH release from pituitary cells. Deleting amino acids from the N-terminus of angiotensin II resulted in decreased CRF activity; while the ED50 for angiotensin II was 2 nM, it increased to about 10 nM for the (2-8)-heptapeptide. Angiotensin I had a weak CRF activity, whereas the substrate angiotensinogen had no stimulatory effect even at a concentration of 100 nM. There was a strong correlation between the activation and binding properties of all peptides tested. Dietary salt load or depletion as well as dexamethasone treatment did not affect the number nor the affinity of pituitary angiotensin II receptors. Angiotensin II had a CRF activity on human pituitary cells in vitro. However, peripherally injected agiotensin II at a pressive dose of 7 ng/kg/min did not produce any ACTH release in normal male volunteers. These data suggest that angiotensin II may play a modulatory role in the physiological regulation of ACTH secretion, but this role might be attributed to the endogenous brain angiotensin II as it is not closely dependent on the angiotensin II plasma levels.
Keywords
Adrenocorticotropic Hormone/*secretion Angiotensin II/metabolism/pharmacology Angiotensins/metabolism/*pharmacology Animals Corticotropin-Releasing Hormone/*physiology Female Humans Pituitary Gland, Anterior/drug effects/*secretion Rats Rats, Inbred Strains Receptors, Angiotensin/metabolism *Renin-Angiotensin System Vasopressins/pharmacology
Pubmed
Web of science
Create date
15/02/2008 17:57
Last modification date
20/08/2019 16:50
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