Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Details
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_D0781ADDDA56
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Journal
Nature genetics
Working group(s)
KidneyGen Consortium, CKDGen Consortium, GUGC consortium
Contributor(s)
Chambers J.C., Zhang W., Lord G.M., van der Harst P., Lawlor D.A., Sehmi J.S., Gale D.P., Wass M.N., Ahmadi K.R., Bakker S.J., Beckmann J., Bilo H.J., Bochud M., Brown M.J., Caulfield M.J., Connell J.M., Cook H.T., Cotlarciuc I., Smith G.D., de Silva R., Deng G., Devuyst O., Dikkeschei L.D., Dimkovic N., Dockrell M., Dominiczak A., Ebrahim S., Eggermann T., Farrall M., Ferrucci L., Floege J., Forouhi N.G., Gansevoort R.T., Han X., Hedblad B., van der Heide J.J., Hepkema B.G., Hernandez-Fuentes M., Hypponen E., Johnson T., de Jong P.E., Kleefstra N., Lagou V., Lapsley M., Li Y., Loos R.J., Luan J., Luttropp K., Maréchal C., Melander O., Munroe P.B., Nordfors L., Parsa A., Peltonen L., Penninx B.W., Perucha E., Pouta A., Prokopenko I., Roderick P.J., Ruokonen A., Samani N.J., Sanna S., Schalling M., Schlessinger D., Schlieper G., Seelen M.A., Shuldiner A.R., Sjögren M., Smit J.H., Snieder H., Soranzo N., Spector T.D., Stenvinkel P., Sternberg M.J., Swaminathan R., Tanaka T., Ubink-Veltmaat L.J., Uda M., Vollenweider P., Wallace C., Waterworth D., Zerres K., Waeber G., Wareham N.J., Maxwell P.H., McCarthy M.I., Jarvelin M.R., Mooser V., Abecasis G.R., Lightstone L., Scott J., Navis G., Elliott P., Kooner J.S., Köttgen A., Pattaro C., Böger C.A., Fuchsberger C., Olden M., Glazer N.L., Parsa A., Gao X., Yang Q., Smith A.V., O'Connell J.R., Li M., Schmidt H., Tanaka T., Isaacs A., Ketkar S., Hwang S.J., Johnson A.D., Dehghan A., Teumer A., Paré G., Atkinson E.J., Zeller T., Lohman K., Cornelis M.C., Probst-Hensch N.M., Kronenberg F., Tönjes A., Hayward C., Aspelund T., Eiriksdottir G., Launer L.J., Harris T.B., Rampersaud E., Mitchell B.D., Arking D.E., Boerwinkle E., Struchalin M., Cavalieri M., Singleton A., Giallauria F., Metter J., de Boer I.H., Haritunians T., Lumley T., Siscovick D., Psaty B.M., Zillikens M.C., Oostra B.A., Feitosa M., Province M., de Andrade M., Turner S.T., Schillert A., Ziegler A., Wild P.S., Schnabel R.B., Wilde S., Munzel T.F., Leak T.S., Illig T., Klopp N., Meisinger C., Wichmann H.E., Koenig W., Zgaga L., Zemunik T., Kolcic I., Minelli C., Hu F.B., Johansson Å., Igl W., Zaboli G., Wild S.H., Wright A.F., Campbell H., Ellinghaus D., Schreiber S., Aulchenko Y.S., Felix J.F., Rivadeneira F., Uitterlinden A.G., Hofman A., Imboden M., Nitsch D., Brandstätter A., Kollerits B., Kedenko L., Mägi R., Stumvoll M., Kovacs P., Boban M., Campbell S., Endlich K., Völzke H., Kroemer H.K., Nauck M., Völker U., Polasek O., Vitart V., Badola S., Parker A.N., Ridker P.M., Kardia S.L., Blankenberg S., Liu Y., Curhan G.C., Franke A., Rochat T., Paulweber B., Prokopenko I., Wang W., Gudnason V., Shuldiner A.R., Coresh J., Schmidt R., Ferrucci L., Shlipak M.G., van Duijn C.M., Borecki I., Krämer B.K., Rudan I., Gyllensten U., Wilson J.F., Witteman J.C., Pramstaller P.P., Rettig R., Hastie N., Chasman D.I., Kao W.H., Heid I.M., Fox C.S., Köttgen A., Albrecht E., Teumer A., Vitart V., Krumsiek J., Hundertmark C., Pistis G., Ruggiero D., O'Seaghdha M., Haller T., Yang Q., Tanaka T., Johnson A.D., Kutalik Z., Smith A.V., Shi J., Struchalin M., Middelberg P.S., Brown M.J., Gaffo A.L., Pirastu N., Li G., Hayward C., Zemunik T., Huffman J., Yengo L., Zhao J.H., Demirkan A., Feitosa M.F., Liu X., Malerba G., Lopez L.M., van der Harst P., Li X., Kleber M.E., Hicks A.A., Nolte I.M., Johansson A., Murgia F., Wild S.H., Bakker S.J., Peden J.F., Dehghan A., Steri M., Tenesa A., Lagou V., Salo P., Mangino M., Rose L.M., Lehtimäki T., Woodward O.M., Okada Y., Tin A., Müller C., Oldmeadow C., Putku M., Czamara D., Kraft P., Frogheri L., Thun G.A., Grotevendt A., Gislason G.K., Harris T.B., Launer L.J., McArdle P., Shuldiner A.R., Boerwinkle E., Coresh J., Schmidt H., Schallert M., Martin N.G., Montgomery G.W., Kubo M., Nakamura Y., Tanaka T., Munroe P.B., Samani N.J., Jacobs D.R., Liu K., D'Adamo P., Ulivi S., Rotter J.I., Psaty B.M., Vollenweider P., Waeber G., Campbell S., Devuyst O., Navaro P., Kolcic I., Hastie N., Balkau B., Froguel P., Esko T., Salumets A., Khaw K.T., Langenberg C., Wareham N.J., Isaacs A., Kraja A., Zhang Q., Wild P.S., Scott R.J., Holliday E.G., Org E., Viigimaa M., Bandinelli S., Metter J.E., Lupo A., Trabetti E., Sorice R., Döring A., Lattka E., Strauch K., Theis F., Waldenberger M., Wichmann H.E., Davies G., Gow A.J., Bruinenberg M., Stolk R.P., Kooner J.S., Zhang W., Winkelmann B.R., Boehm B.O., Lucae S., Penninx B.W., Smit J.H., Curhan G., Mudgal P., Plenge R.M., Portas L., Persico I., Kirin M., Wilson J.F., Mateo Leach I., van Gilst W.H., Goel A., Ongen H., Hofman A., Rivadeneira F., Uitterlinden A.G., Imboden M., von Eckardstein A., Cucca F., Nagaraja R., Piras M.G., Nauck M., Schurmann C., Budde K., Ernst F., Farrington S.M., Theodoratou E., Prokopenko I., Stumvoll M., Jula A., Perola M., Salomaa V., Shin S.Y., Spector T.D., Sala C., Ridker P.M., Kähönen M., Viikari J., Hengstenberg C., Nelson C.P., Meschia J.F., Nalls M.A., Sharma P., Singleton A.B., Kamatani N., Zeller T., Burnier M., Attia J., Laan M., Klopp N., Hillege H.L., Kloiber S., Choi H., Pirastu M., Tore S., Probst-Hensch N.M., Völzke H., Gudnason V., Parsa A., Schmidt R., Whitfield J.B., Fornage M., Gasparini P., Siscovick D.S., Polasek O., Campbell H., Rudan I., Bouatia-Naji N., Metspalu A., Loos R.J., van Duijn C.M., Borecki I.B., Ferrucci L., Gambaro G., Deary I.J., Wolffenbuttel B.H., Chambers J.C., März W., Pramstaller P.P., Snieder H., Gyllensten U., Wright A.F., Navis G., Watkins H., Witteman J.C., Sanna S., Schipf S., Dunlop M.G., Tönjes A., Ripatti S., Soranzo N., Toniolo D., Chasman D.I., Raitakari O., Kao W.H., Ciullo M., Fox C.S., Caulfield M., Bochud M., Gieger C.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
15/07/2012
Peer-reviewed
Oui
Volume
44
Number
8
Pages
904-909
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Keywords
Asian Continental Ancestry Group/genetics, Blood Urea Nitrogen, Cohort Studies, Creatinine/blood, Genetic Predisposition to Disease, Genome-Wide Association Study, Glomerular Filtration Rate/genetics, Humans, Kidney/physiology, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic/genetics, Uric Acid/blood
Pubmed
Create date
22/10/2012 15:10
Last modification date
20/08/2019 15:50
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