Bridging the gaps towards precision psychiatry: Mechanistic biomarkers for early detection and intervention.

Details

Serval ID
serval:BIB_D0755526E458
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bridging the gaps towards precision psychiatry: Mechanistic biomarkers for early detection and intervention.
Journal
Psychiatry research
Author(s)
Do K.Q.
ISSN
1872-7123 (Electronic)
ISSN-L
0165-1781
Publication state
Published
Issued date
03/2023
Peer-reviewed
Oui
Volume
321
Pages
115064
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Early detection and intervention in schizophrenia, improving prognosis, requires mechanism-based biomarkers that capture circuitry dysfunction, allowing optimized patient stratification, disease monitoring and treatment. Dr. Do's translational research, bridging basic neuroscience and clinical psychiatry, tackles an urgent need to develop effective treatments that target mechanisms underlying cognitive deficits, a critical dimension of schizophrenia, currently not well treated. By adopting a reverse translation of validated circuitry relevant human endpoints, her research brought new insights in mechanism-based biomarker guided treatment of patients in early stages of psychosis. She showed that oxidative stress/redox dysregulation, in reciprocal interaction with dopamine imbalance, NMDAR hypofunction, neuroinflammation and mitochondrial bioenergetic dysfunction, may represent a "hub" on which both genetic and environmental risk factors converge during neurodevelopment. This leads to impairments of structural and functional connectivity in microcircuits, involving impaired parvalbumin fast-spiking GABA neurons, and macrocircuits, impacting myelination of fiber tracts, at the basis of neural synchronization abnormalities, as well as sensory and cognitive deficits. These unique insights led to successful proof-of-concept clinical trials, targeting oxidative stress through antioxidant-based strategies in patients at various disease stages, paving the way for precision medicine in psychiatry.
Keywords
Humans, Biomarkers, Cognition Disorders, Schizophrenia, Psychotic Disorders, Psychiatry, Receptors, N-Methyl-D-Aspartate, Critical period plasticity, Excitatory-inhibitory balance, Myelination, Neural synchronization, Neurodevelopment, Neuroinflammation, NMDA receptor hypofunction, mitochondria, parvalbumin, Oligodendrocytes, Oxidative stress, Redox dysregulation, Trauma, White matter
Pubmed
Web of science
Create date
03/03/2023 17:47
Last modification date
16/11/2023 8:11
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