How useful is PET/CT imaging in the management of post-transplant lymphoproliferative disease after liver transplantation?

Details

Serval ID
serval:BIB_D0595E7F5518
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
How useful is PET/CT imaging in the management of post-transplant lymphoproliferative disease after liver transplantation?
Journal
American Journal of Transplantation
Author(s)
McCormack L., Hany T.I., Hübner M., Petrowsky H., Mullhaupt B., Knuth A., Stenner F., Clavien P.A.
ISSN
1600-6135 (Print)
ISSN-L
1600-6135
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
6
Number
7
Pages
1731-1736
Language
english
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Post-transplant lymphoproliferative disease (PTLD) is a serious and potentially life-threatening complication after solid organ transplantation. Here, we report our first experience with the use of PET/CT (positron emission tomography combined with computed tomogram) for the management of patients with PTLD after liver transplantation. Four patients with histologically proven PTLD were analyzed. Conventional work-up included physical examination and head-to-pelvis CT. PET/CT was used in one patient for initial staging and in all patients for follow-up. PET/CT positive findings underwent biopsy. Information provided by PET/CT resulted in a change of medical management in three of the four patients. Conventional work-up missed residual disease after surgery in one and failed to detect a tumor relapse in another patient. However, one patient disclosed a false positive PET/CT finding in the lungs. In conclusion, PET/CT may be a useful tool for staging and therapy monitoring of PTLD after liver transplantation.
Keywords
Adolescent, Female, Humans, Liver Transplantation/radiography, Liver Transplantation/radionuclide imaging, Lymphoproliferative Disorders/radiography, Lymphoproliferative Disorders/radionuclide imaging, Middle Aged, Positron-Emission Tomography/methods, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2012 11:21
Last modification date
20/08/2019 15:50
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