Three clonal types of keratinocyte with different capacities for multiplication

Details

Serval ID
serval:BIB_D051B97D9EE3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Three clonal types of keratinocyte with different capacities for multiplication
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Barrandon  Y., Green  H.
ISSN
0027-8424 (Print)
Publication state
Published
Issued date
04/1987
Volume
84
Number
8
Pages
2302-6
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Abstract
Colony-forming human epidermal cells are heterogeneous in their capacity for sustained growth. Once a clone has been derived from a single cell, its growth potential can be estimated from the colony types resulting from a single plating, and the clone can be assigned to one of three classes. The holoclone has the greatest reproductive capacity: under standard conditions, fewer than 5% of the colonies formed by the cells of a holoclone abort and terminally differentiate. The paraclone contains exclusively cells with a short replicative lifespan (not more than 15 cell generations), after which they uniformly abort and terminally differentiate. The third type of clone, the meroclone, contains a mixture of cells of different growth potential and is a transitional stage between the holoclone and the paraclone. The incidence of the different clonal types is affected by aging, since cells originating from the epidermis of older donors give rise to a lower proportion of holoclones and a higher proportion of paraclones.
Keywords
Cell Division Cells, Cultured Clone Cells Epidermis/*cytology Humans Keratins/metabolism Kinetics
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:41
Last modification date
20/08/2019 16:50
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