Self-navigated isotropic three-dimensional cardiac T2 mapping.

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State: Public
Version: Final published version
Serval ID
serval:BIB_D042DF1D7523
Type
Article: article from journal or magazin.
Collection
Publications
Title
Self-navigated isotropic three-dimensional cardiac T2 mapping.
Journal
Magnetic Resonance In Medicine
Author(s)
van Heeswijk R.B., Piccini D., Feliciano H., Hullin R., Schwitter J., Stuber M.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
73
Number
4
Pages
1549-1554
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
PURPOSE: To implement and characterize an isotropic three-dimensional cardiac T2 mapping technique.
METHODS: A self-navigated three-dimensional radial segmented balanced steady-state free precession pulse sequence with an isotropic 1.7-mm spatial resolution was implemented at 3T with a variable T2 preparation module. Bloch equation and Monte Carlo simulations were performed to determine the influence of the heart rate, B1 inhomogeneity and noise on the T2 fitting accuracy. In a phantom study, the accuracy of the pulse sequence was studied through comparison with a gold-standard spin-echo T2 mapping method. The robustness and homogeneity of the technique were ascertained in a study of 10 healthy adult human volunteers, while first results obtained in patients are reported.
RESULTS: The numerical simulations demonstrated that the heart rate and B1 inhomogeneity cause only minor deviations in the T2 fitting, whereas the phantom study showed good agreement of the technique with the gold standard. The volunteer study demonstrated an average myocardial T2 of 40.5 ± 3.3 ms and a <15% T2 gradient in the base-apex and anterior-inferior direction. In three patients, elevated T2 values were measured in regions with expected edema.
CONCLUSION: This respiratory self-navigated isotropic three-dimensional technique allows for accurate and robust in vitro and in vivo T2 quantification. Magn Reson Med 73:1549-1554, 2015. © 2014 Wiley Periodicals, Inc.
Pubmed
Web of science
Open Access
Yes
Create date
22/07/2014 14:24
Last modification date
20/08/2019 16:50
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