Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.

Details

Ressource 1Download: 38576000.pdf (971.29 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_D03E382E48C8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.
Journal
Journal of occupational medicine and toxicology
Author(s)
Freund R., Sauvain J.J., Suarez G., Wild P., Charreau T., Debatisse A., Sakthithasan K., Jouannique V., Pralong J.A., Guseva Canu I.
ISSN
1745-6673 (Print)
ISSN-L
1745-6673
Publication state
Published
Issued date
04/04/2024
Peer-reviewed
Oui
Volume
19
Number
1
Pages
10
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients.
Three hundred three participants were randomly selected from a 15,000-transit worker cohort within the Respiratory disease Occupational Biomonitoring Collaborative Project (ROBoCoP). COPD was defined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as post-bronchodilator ratio of Forced Expiratory Volume in 1st second to Forced Vital Capacity < 0.7 in spirometry validated by an experienced pulmonologist. Discriminative power of biomarker profiles in EBC was analyzed using linear discriminant analyses.
Amongst 300 participants with validated spirometry, 50.3% were female, 52.3 years old in average, 36.0% were current smokers, 12.7% ex-smokers with mean tobacco exposure of 15.4 pack-years. Twenty-one participants (7.0%) were diagnosed as COPD, including 19 new diagnoses, 12 of which with a mild COPD stage (GOLD 1). Amongst 8 biomarkers measured in EBC, combination of 2 biomarkers, Lactate and Malondialdehyde (MDA) significantly discriminated COPD subjects from non-COPD, with a 71%-accuracy, area under the receiver curve of 0.78 (p-value < 0.001), and a negative predictive value of 96%.
These findings support the potential of biomarkers in EBC, in particular lactate and MDA, to discriminate COPD patients even at a mild or moderate stage. These EBC biomarkers present a non-invasive and drugless technique, which can improve COPD diagnosis in the future.
Keywords
Biomarker, COPD, Exhaled breath condensate, Oxidative stress, Respiratory
Pubmed
Open Access
Yes
Create date
08/04/2024 14:16
Last modification date
09/04/2024 7:25
Usage data