Host determinants of HIV-1 control in African Americans.

Details

Serval ID
serval:BIB_D022A18CA654
Type
Article: article from journal or magazin.
Collection
Publications
Title
Host determinants of HIV-1 control in African Americans.
Journal
Journal of Infectious Diseases
Author(s)
Pelak K., Goldstein D.B., Walley N.M., Fellay J., Ge D., Shianna K.V., Gumbs C., Gao X., Maia J.M., Cronin K.D., Hussain S.K., Carrington M., Michael N.L., Weintrob A.C.
Working group(s)
Infectious Disease Clinical Research Program HIV Working Group, National Institute of Allergy, Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)
Contributor(s)
Polis M., Powers J., Tramont E., Maguire J., Bavaro M., Crum-Cianflone N., Chun H., Decker C., Ganesan A., Whitman T., Bradley W., Marconi V., Merritt S., Okulicz J., Johnson A., Agan B., Eggleston C., Jagodzinski L., O'Connell R., Peel S., Hawkes C., Wortmann G., Zapor M., Eberly L., Lifson A.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
2010
Volume
201
Number
8
Pages
1141-1149
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
Keywords
Adolescent, Adult, African Americans/genetics, DNA-Binding Proteins/genetics, DNA-Binding Proteins/immunology, Disease Progression, Genome-Wide Association Study, Genotype, HIV Infections/genetics, HIV Infections/immunology, HIV-1/immunology, HLA-B Antigens/genetics, HLA-B Antigens/immunology, HLA-C Antigens/genetics, HLA-C Antigens/immunology, Humans, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide/genetics, Viral Load/genetics, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
01/03/2012 15:14
Last modification date
20/08/2019 15:50
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