Sodium valproate does not alter immune competence in mice.
Details
Serval ID
serval:BIB_D01D9F6ED59A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sodium valproate does not alter immune competence in mice.
Journal
Immunopharmacology and Immunotoxicology
ISSN
0892-3973 (Print)
ISSN-L
0892-3973
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
11
Number
4
Pages
593-602
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Spleen and thymus weight, delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC), contact hypersensitivity to picryl chloride, anti-sheep red blood cell hemagglutinin titers and plaque-forming cells (PFC), resistance against experimental toxoplasmosis as well as serum total and intestinal specific IgA were investigated in Swiss mice given sodium valproate (250 mg/kg/day) orally for 21 consecutive days. Sodium valproate (SV) did not exert marked effects as only DTH to SRBC and PFC numbers were found to be slightly altered. These results suggest that SV is unlikely to alter immune competence markedly.
Keywords
Adjuvants, Immunologic, Animals, Antibody-Producing Cells/drug effects, Female, Hypersensitivity, Delayed, Immunocompetence/drug effects, Immunoglobulin A/biosynthesis, Immunosuppressive Agents, Male, Mice, Valproic Acid/administration & dosage, Valproic Acid/toxicity
Pubmed
Create date
13/10/2015 9:46
Last modification date
20/08/2019 16:50