The Potential Interest of Topiramate in Addictions

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State: Public
Version: Final published version
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Serval ID
serval:BIB_D007973AFDE2
Type
Article: article from journal or magazin.
Collection
Publications
Title
The Potential Interest of Topiramate in Addictions
Journal
Current Pharmaceutical Design
Author(s)
Thorens Gabriel, Billieux Joel, Manghi Rita, Khan Riaz, Khazaal Yasser, Fabio Zullino Daniele
ISSN
1381-6128
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
17
Number
14
Pages
1410-1415
Language
english
Abstract
Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if a too broad effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described.
Keywords
Topiramate, Addiction
Pubmed
Web of science
Create date
10/01/2020 9:31
Last modification date
23/01/2020 16:57
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