Cardiac mass in glucocorticoid-hypertensive rats with and without circulating adrenaline.

Details

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State: Public
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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_CFF5D830CA18
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cardiac mass in glucocorticoid-hypertensive rats with and without circulating adrenaline.
Journal
Cardiovascular research
Author(s)
Burris J.F., Waeber B., Brunner H.R.
ISSN
0008-6363 (Print)
ISSN-L
0008-6363
Publication state
Published
Issued date
12/1985
Peer-reviewed
Oui
Volume
19
Number
12
Pages
734-736
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
There is evidence that catecholamines may promote the development of cardiac hypertrophy in hypertension. To test the hypothesis that adrenaline directly determines left ventricular mass, normotensive Wistar rats were made adrenaline-deficient by adrenalectomy and hypertensive by administration of glucocorticoid. Blood pressure, heart rate, and body weight of the adrenalectomised group were not significantly different from a glucocorticoid treated control group with intact adrenals. Heart weight was significantly lower in the adrenalectomised rats, but this difference disappeared when heart weight was adjusted for body weight. It appears therefore that the presence or absence of adrenaline does not significantly affect cardiac mass in the presence of hypertension in this animal model.
Keywords
Adrenalectomy, Animals, Body Weight, Epinephrine/blood, Heart Rate, Heart Ventricles/pathology, Hypertension/blood, Hypertension/pathology, Male, Myocardium/pathology, Organ Size, Rats, Rats, Inbred Strains
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 10:06
Last modification date
01/10/2019 6:19
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